中国医学前沿杂志(电子版)
中國醫學前沿雜誌(電子版)
중국의학전연잡지(전자판)
CHINESE JOURNAL OF THE FRONTIERS OF MEDICAL SCIENCE(ELECTRONIC VERSION)
2014年
10期
92-94
,共3页
原发性肾病综合征%尿路感染%危险因素
原髮性腎病綜閤徵%尿路感染%危險因素
원발성신병종합정%뇨로감염%위험인소
Primary nephrotic syndrome%Urinary tract infection%Risk factors
目的:探讨原发性肾病综合征(PNS)患者并发尿路感染(UTI)的危险因素,为诊断和治疗PNS并发UTI提供临床参考依据。方法对2007年2月至2013年10月本院收治的570例PNS患者中并发UTI的154例患者(试验组)的临床资料进行回顾性分析,随机选取154例单纯PNS患者作为对照组,比较两组患者各项生化指标,分析PNS并发UTI的相关单因素,包括性别、年龄、并发症、激素使用剂量以及免疫抑制剂的使用情况等,探究各项指标、单因素与PNS并发UTI的关系。结果570例PNS患者中154例并发UTI,感染发生率为27.0%;与对照组患者相比,试验组患者的尿蛋白、血清蛋白、脂蛋白a[Lp(a)]、免疫球蛋白G(IgG)和低密度脂蛋白(LDL)水平均有显著变化(P<0.05);而胆固醇、高密度脂蛋白(HDL)、免疫球蛋白M(IgM)和免疫球蛋白A (IgA)水平则无显著变化(P>0.05);单因素分析结果显示,UTI发生率与性别无关,不同年龄段的患者UTI发生率:少儿组>老年组>青壮年组,组间比较差异均有显著性(P<0.05);使用免疫抑制剂、高剂量的激素以及合并其他疾病均能显著提高UTI的发生率(P<0.05)。结论低血清蛋白、低IgG血症、高蛋白尿、高LDL和(或)Lp(a)可能提示PNS并发UTI的发生。年龄、并发症、有无使用免疫抑制剂和激素使用浓度可能是引发UTI的危险因素。
目的:探討原髮性腎病綜閤徵(PNS)患者併髮尿路感染(UTI)的危險因素,為診斷和治療PNS併髮UTI提供臨床參攷依據。方法對2007年2月至2013年10月本院收治的570例PNS患者中併髮UTI的154例患者(試驗組)的臨床資料進行迴顧性分析,隨機選取154例單純PNS患者作為對照組,比較兩組患者各項生化指標,分析PNS併髮UTI的相關單因素,包括性彆、年齡、併髮癥、激素使用劑量以及免疫抑製劑的使用情況等,探究各項指標、單因素與PNS併髮UTI的關繫。結果570例PNS患者中154例併髮UTI,感染髮生率為27.0%;與對照組患者相比,試驗組患者的尿蛋白、血清蛋白、脂蛋白a[Lp(a)]、免疫毬蛋白G(IgG)和低密度脂蛋白(LDL)水平均有顯著變化(P<0.05);而膽固醇、高密度脂蛋白(HDL)、免疫毬蛋白M(IgM)和免疫毬蛋白A (IgA)水平則無顯著變化(P>0.05);單因素分析結果顯示,UTI髮生率與性彆無關,不同年齡段的患者UTI髮生率:少兒組>老年組>青壯年組,組間比較差異均有顯著性(P<0.05);使用免疫抑製劑、高劑量的激素以及閤併其他疾病均能顯著提高UTI的髮生率(P<0.05)。結論低血清蛋白、低IgG血癥、高蛋白尿、高LDL和(或)Lp(a)可能提示PNS併髮UTI的髮生。年齡、併髮癥、有無使用免疫抑製劑和激素使用濃度可能是引髮UTI的危險因素。
목적:탐토원발성신병종합정(PNS)환자병발뇨로감염(UTI)적위험인소,위진단화치료PNS병발UTI제공림상삼고의거。방법대2007년2월지2013년10월본원수치적570례PNS환자중병발UTI적154례환자(시험조)적림상자료진행회고성분석,수궤선취154례단순PNS환자작위대조조,비교량조환자각항생화지표,분석PNS병발UTI적상관단인소,포괄성별、년령、병발증、격소사용제량이급면역억제제적사용정황등,탐구각항지표、단인소여PNS병발UTI적관계。결과570례PNS환자중154례병발UTI,감염발생솔위27.0%;여대조조환자상비,시험조환자적뇨단백、혈청단백、지단백a[Lp(a)]、면역구단백G(IgG)화저밀도지단백(LDL)수평균유현저변화(P<0.05);이담고순、고밀도지단백(HDL)、면역구단백M(IgM)화면역구단백A (IgA)수평칙무현저변화(P>0.05);단인소분석결과현시,UTI발생솔여성별무관,불동년령단적환자UTI발생솔:소인조>노년조>청장년조,조간비교차이균유현저성(P<0.05);사용면역억제제、고제량적격소이급합병기타질병균능현저제고UTI적발생솔(P<0.05)。결론저혈청단백、저IgG혈증、고단백뇨、고LDL화(혹)Lp(a)가능제시PNS병발UTI적발생。년령、병발증、유무사용면역억제제화격소사용농도가능시인발UTI적위험인소。
ObjectiveTo investigate the risk factors in primary nephrotic syndrome (PNS) patients with urinary tract infections (UTI) and provide clinical reference for the prevention of urinary tract infection. MethodFrom February 2007 to October 2013, the clinical data of 570 cases with PNS combined with 154 cases of UTI were retrospectively analyzed. Through the comparative analysis of two groups and the statistical analysis of related factors (including gender, age, complications, hormone dosage and immunosuppressor) in 154 cases of PNS combined with UTI, in order to ifnd the relations between various factors and primary nephrotic syndrome of urinary tract infections.Result154 cases were urinary tract infection in 570 cases with PNS, and the incidence of infection was 27.0%; compared with patients with no UTI complication, the content of the urine protein, serum protein, lipoprotein (a) [Lp(a)], IgG and low density lipoprotein (LDL) in patients with PNS combined with UTI had signiifcant changes (P<0.05). However, the content of cholesterol, high-density lipoprotein (HDL), IgM and IgA had no signiifcant differences (P>0.05). The results of single factor showed that the incidence of urinary tract infection was not related with age. In different stages of age, the incidence of children was greater than seniors and young adults. Two groups had signiifcant difference (P<0.05). Patients can improve the incidence of UTI (P<0.05) by the use of immunosuppressor and high doses of hormones and other complications.ConclusionLow serum proteinemia, low IgG emesis emia, high proteinuria, high LDL and (or) Lp(a) may indicate the incidence of primary nephrotic syndrome combined with urinary tract infections. Age, complications, with or without the use of immunosuppressor and concentration of hormone may be risk factors of causing urinary tract infection.