CAJ | 학술논문

目的：探讨肺癌患者白细胞介素10（IL-10）与25-羟基维生素D检测的临床价值。方法：收集本院2012年3月-2013年1月新入院肺癌患者78例，其中腺癌40例，鳞状细胞癌28例，小细胞癌10例，选取年龄和性别与其相匹配的50例健康体检者作为对照组。分析25-羟维生素D与IL-10在各组间的差异及其相关性。结果：肺癌患者血浆25-羟基维生素D浓度为（24.5±6.8）ng/mL，低于健康对照组的（35.1±8.7）ng/mL；肺癌患者血浆IL-10浓度为1031ng/L[（805～1243）ng/L]，高于健康对照组的445ng/L[（320～580） ng/L]，差异均有统计学意义（均P＜0.05）。肺腺癌患者血浆25-羟基维生素D浓度与肺鳞状细胞癌患者比较差异无统计学意义（P＞0.05）；肺腺癌患者血浆IL-10浓度为1255ng/L[（1050～1440）ng/L]，高于肺鳞状细胞癌患者的840ng/L[（530～1010）ng/L]，差异有统计学意义（P＜0.05）。肺癌患者血浆IL-10与25-羟基维生素D不存在相关性（r=-0.011，P＞0.05）。结论：肺癌患者血浆25-羟基维生素D与IL-10浓度异常，提示肺癌患者血浆25-羟基维生素D与IL-10浓度检测对治疗和预后监测具有一定临床价值。
목적：탐토폐암환자백세포개소10（IL-10）여25-간기유생소D검측적림상개치。방법：수집본원2012년3월-2013년1월신입원폐암환자78례，기중선암40례，린상세포암28례，소세포암10례，선취년령화성별여기상필배적50례건강체검자작위대조조。분석25-간유생소D여IL-10재각조간적차이급기상관성。결과：폐암환자혈장25-간기유생소D농도위（24.5±6.8）ng/mL，저우건강대조조적（35.1±8.7）ng/mL；폐암환자혈장IL-10농도위1031ng/L[（805～1243）ng/L]，고우건강대조조적445ng/L[（320～580） ng/L]，차이균유통계학의의（균P＜0.05）。폐선암환자혈장25-간기유생소D농도여폐린상세포암환자비교차이무통계학의의（P＞0.05）；폐선암환자혈장IL-10농도위1255ng/L[（1050～1440）ng/L]，고우폐린상세포암환자적840ng/L[（530～1010）ng/L]，차이유통계학의의（P＜0.05）。폐암환자혈장IL-10여25-간기유생소D불존재상관성（r=-0.011，P＞0.05）。결론：폐암환자혈장25-간기유생소D여IL-10농도이상，제시폐암환자혈장25-간기유생소D여IL-10농도검측대치료화예후감측구유일정림상개치。
Objective: To investigate plasma interleukin-10 (IL-10) and 25 (OH) vitamin D in patients with lung cancer and its clinical value.Methods: From March 2012 to January 2013, 78 cases newly admitted patients with lung cancer in our hospital were enrolled, including 40 cases of adenocarcinoma, 28 cases squamous cell carcinoma, 10 cases of small cell carcinoma, select age and sex matched 50 healthy volunteers as a control group. Analysis of 25 (OH) vitamin D and IL-10 in the differences among the groups and their correlation.Results:Lung cancer patients plasma 25 (OH) vitamin D concentration were (24.5±6.8) ng/mL, lower than the healthy control group 35.1±8.7 ng/mL, lung cancer patients plasma IL-10 concentrations were 1 031 (805~1 243) ng/L, higher than the healthy control group, the difference was statistically signiifcant (P<0.05); lung adenocarcinoma patients plasma 25 (OH) vitamin D concentrations was not statistically signiifcant difference in patients with squamous cell carcinoma of lung (P>0.05), lung adenocarcinoma patients plasma concentrations of IL-10 were 1 255 (1 050~1 440) ng/L, higher than that in patients with squamous cell carcinoma of lung, the difference was statistically signiifcant (P<0.05), there is no correlation of plasma IL-10 and 25 (OH) vitamin D in patients with lung cancer (r=-0.011,P>0.05).Conclusion: Plasma 25 (OH) vitamin D and IL-10 concentration anomalies in patients with lung cancer, we suggesting that plasma 25 (OH) vitamin D and IL-10 concentration detection are helpful for monitoring the treatment and prognosis of patients with lung cancer.