CAJ | 학술논문

目的：调查河南省汉族居民丙型肝炎病毒（ HCV）感染的危险因素，并分析其与HCV感染的相关性。方法于2013年6—9月以河南省2012年7家开展丙型肝炎诊治的医院为研究场所，按照1∶1配对的病例-对照研究原则，调查了134对研究对象。病例组的纳入标准为：汉族，2013年首次诊断为丙型肝炎，现住址与调查地属同一区（县）级范围的≥18岁患者；排除标准为：不能配合调查或明确为丙型肝炎晚期的患者。对照组的纳入标准为：汉族，与配对的病例组患者同性别、正在同一医院就诊、来自于同一区（县）、年龄在同一年龄组且相差≤5岁的其他病患者。排除标准为：不能配合调查或有明确血清学检测结果判定为乙型肝炎、丙型肝炎患者。采集静脉血3 ml，检测其抗-HCV水平。采用χ2检验进行病例组和对照组丙型肝炎感染危险因素的单因素分析，采用多因素回归模型分析HCV感染的危险因素。结果病例组卖血、输血、做手术、扎针灸比例分别为35畅1％（47／134）、27畅6％（37／134）、42畅5％（57／134）、12畅7％（17／134），均高于对照组[分别为2畅2％（3／134）、5畅2％（7／134）、21畅6％（29／134）、5畅2％（7／134）]（χ2值分别为47畅60、24畅47、13畅42、4畅58， P值均＜0畅05）。输血者和卖血者HCV感染风险分别是不输血者和不卖血者的2畅01（1畅32～3畅05）、2畅68（1畅85～3畅88）倍。进一步多因素非条件logistic回归分析显示，卖血浆者和卖全血者HCV感染风险分别是未卖过血浆者和未卖过全血者的76畅71（10畅25～574畅25）、10畅23（2畅15～48畅70）倍。结论卖血和输血均是河南省汉族居民HCV感染的独立危险因素。其中，卖血浆、卖全血者HCV感染风险较其他卖血、输血者增大。
목적：조사하남성한족거민병형간염병독（ HCV）감염적위험인소，병분석기여HCV감염적상관성。방법우2013년6—9월이하남성2012년7가개전병형간염진치적의원위연구장소，안조1∶1배대적병례-대조연구원칙，조사료134대연구대상。병례조적납입표준위：한족，2013년수차진단위병형간염，현주지여조사지속동일구（현）급범위적≥18세환자；배제표준위：불능배합조사혹명학위병형간염만기적환자。대조조적납입표준위：한족，여배대적병례조환자동성별、정재동일의원취진、래자우동일구（현）、년령재동일년령조차상차≤5세적기타병환자。배제표준위：불능배합조사혹유명학혈청학검측결과판정위을형간염、병형간염환자。채집정맥혈3 ml，검측기항-HCV수평。채용χ2검험진행병례조화대조조병형간염감염위험인소적단인소분석，채용다인소회귀모형분석HCV감염적위험인소。결과병례조매혈、수혈、주수술、찰침구비례분별위35창1％（47／134）、27창6％（37／134）、42창5％（57／134）、12창7％（17／134），균고우대조조[분별위2창2％（3／134）、5창2％（7／134）、21창6％（29／134）、5창2％（7／134）]（χ2치분별위47창60、24창47、13창42、4창58， P치균＜0창05）。수혈자화매혈자HCV감염풍험분별시불수혈자화불매혈자적2창01（1창32～3창05）、2창68（1창85～3창88）배。진일보다인소비조건logistic회귀분석현시，매혈장자화매전혈자HCV감염풍험분별시미매과혈장자화미매과전혈자적76창71（10창25～574창25）、10창23（2창15～48창70）배。결론매혈화수혈균시하남성한족거민HCV감염적독립위험인소。기중，매혈장、매전혈자HCV감염풍험교기타매혈、수혈자증대。
Objective To study the risk factors of hepatitis C Virus Infection among Han population in Henan Province , providing evidence for the development of targeted prevention and control measures .Methods In this 1∶1 matched case-control study, data of 134 cases and 134 controls were collected in seven hospitals from June 2013 to September 2013.Case group with the following conditions: Han nationality, first diagnosed hepatitis C in 2013, Current address and investigation belong to the same district ( county ) , above 18 years old;with the following conditions can′t into case group:not to cooperate with the investigation , late-stage Hepatitis C patients.Control group with the following conditions: Han nationality , with the matched case patients the same gender , in the same hospital for treatment ,from the same district ( county ) , the age difference ≤5 years old and in the same age group.With the following conditions can′t into control group:not to cooperate with the investigation , diagnosed with hepatitis B , hepatitis C patients.Collect 3 ml blood samples to test anti-HCV.Single factors were analyzed with χ2 between case and control , risk factors were analyzed with logistic regression model.Results The ratio about blood donation , blood transfusion,operation and acupuncture of cases were 35.1%(47/134),27.6%(37/134),42.5%(57/134),12.7%(17/134),with differences compared to those of controls (2.2%(3/134),5.2%(7/134), 21.6%(29/134),5.2%(7/134))(χ2 values were 47.60,24.47,13.42 and 4.58,all P values <0.05). Compared with those never received blood transfusion and those never donated blood , former blood receptors and blood donors had higher risk of hepatitis C infection ( OR:2.01,95%CI:1.32-3.05;OR:2.68,95%CI:1.85-3.88).Results of multiple nonconditional logistic regression analysis showed that Plasma donors and whole blood donors had higher risk of hepatitis C infection than those never donated plasma and blood ( OR:76.71,95%CI: 10.25-574.25; OR:10.23,95%CI: 2.15-48.70).Conclusion Blood transfusion and abnormal blood are independent risk factors among Han population in Henan Province of hepatitis C infection.The Plasma donors ,blood donors and with the increase in the times of blood transfusion , the risk of hepatitis C infection is increase.