中国急救医学
中國急救醫學
중국급구의학
CHINESE JOURNAL OF CRITICAL CARE MEDICINE
2014年
12期
1108-1110,1111
,共4页
周杨%张玉良%陆建强%丁凡
週楊%張玉良%陸建彊%丁凡
주양%장옥량%륙건강%정범
脊柱爆裂性骨折%脊髓损伤%血清炎性指标%神经功能指标
脊柱爆裂性骨摺%脊髓損傷%血清炎性指標%神經功能指標
척주폭렬성골절%척수손상%혈청염성지표%신경공능지표
Spinal burst fracture%Spinal cord injury%Serum inflammatory markers%Nerve function index
目的：探究脊柱爆裂性骨折伴脊髓损伤后患者血清炎性指标与神经功能指标的变化情况。方法纳入我院2013－02～2014－0594例入院治疗的脊柱爆裂性骨折伴脊髓损伤患者作为实验组，另随机筛选100例脊柱骨折不伴有脊髓损伤的患者作为对照组。两组样本均进行血清炎性指标及神经功能指标的检查，实验组患者相关指标术前及术后1、3、7、14 d变化情况均与对照组比较，观察患者血清指标及神经功能指标的变化情况。结果脊柱爆裂性骨折伴脊髓损伤患者血清中IL－2（5．21±0．43）μg／mL明显低于对照组（8．83±0．80）μg／mL，而IL－6（8．32±0．69）pg／mL、IL－8（8．79±0．75）pg／mL、TNF－α（1．25±0．12）ng／mL、IL－4（224．72±20．95） ng／mL、IL－10（19．58±1．99）pg／mL、IL－13（6．32±0．67）ng／mL、TGF－β（886．73±78畅72）pg／mL、NSE（18．77±1．77）μg／mL、NGF（386．76±28．48）pg／mL及S100B（0．52±0．10）ng／mL明显高于对照组；炎性因子及神经功能指标的变化与疾病的发生具有明显的相关关系。结论脊柱爆裂性骨折伴脊髓损伤患者炎性指标及神经功能指标变化情况的研究为临床诊断及治疗该疾病提供了有效的科学依据，具有重要的意义。
目的：探究脊柱爆裂性骨摺伴脊髓損傷後患者血清炎性指標與神經功能指標的變化情況。方法納入我院2013－02～2014－0594例入院治療的脊柱爆裂性骨摺伴脊髓損傷患者作為實驗組，另隨機篩選100例脊柱骨摺不伴有脊髓損傷的患者作為對照組。兩組樣本均進行血清炎性指標及神經功能指標的檢查，實驗組患者相關指標術前及術後1、3、7、14 d變化情況均與對照組比較，觀察患者血清指標及神經功能指標的變化情況。結果脊柱爆裂性骨摺伴脊髓損傷患者血清中IL－2（5．21±0．43）μg／mL明顯低于對照組（8．83±0．80）μg／mL，而IL－6（8．32±0．69）pg／mL、IL－8（8．79±0．75）pg／mL、TNF－α（1．25±0．12）ng／mL、IL－4（224．72±20．95） ng／mL、IL－10（19．58±1．99）pg／mL、IL－13（6．32±0．67）ng／mL、TGF－β（886．73±78暢72）pg／mL、NSE（18．77±1．77）μg／mL、NGF（386．76±28．48）pg／mL及S100B（0．52±0．10）ng／mL明顯高于對照組；炎性因子及神經功能指標的變化與疾病的髮生具有明顯的相關關繫。結論脊柱爆裂性骨摺伴脊髓損傷患者炎性指標及神經功能指標變化情況的研究為臨床診斷及治療該疾病提供瞭有效的科學依據，具有重要的意義。
목적：탐구척주폭렬성골절반척수손상후환자혈청염성지표여신경공능지표적변화정황。방법납입아원2013－02～2014－0594례입원치료적척주폭렬성골절반척수손상환자작위실험조，령수궤사선100례척주골절불반유척수손상적환자작위대조조。량조양본균진행혈청염성지표급신경공능지표적검사，실험조환자상관지표술전급술후1、3、7、14 d변화정황균여대조조비교，관찰환자혈청지표급신경공능지표적변화정황。결과척주폭렬성골절반척수손상환자혈청중IL－2（5．21±0．43）μg／mL명현저우대조조（8．83±0．80）μg／mL，이IL－6（8．32±0．69）pg／mL、IL－8（8．79±0．75）pg／mL、TNF－α（1．25±0．12）ng／mL、IL－4（224．72±20．95） ng／mL、IL－10（19．58±1．99）pg／mL、IL－13（6．32±0．67）ng／mL、TGF－β（886．73±78창72）pg／mL、NSE（18．77±1．77）μg／mL、NGF（386．76±28．48）pg／mL급S100B（0．52±0．10）ng／mL명현고우대조조；염성인자급신경공능지표적변화여질병적발생구유명현적상관관계。결론척주폭렬성골절반척수손상환자염성지표급신경공능지표변화정황적연구위림상진단급치료해질병제공료유효적과학의거，구유중요적의의。
Objective The present study aims to detect the changes of serum inflammatory markers and nerve function index in patients with spinal burst fracture combined with spinal cord injury . Methods From February 2013 to May 2014 in our hospital 94 cases admitted for treatment of spinal burst fracture with spinal cord injury were treated as the experimental group , 100 randomly selected cases of spinal fracture without spinal cord injury as control group .The two groups were examined the serum inflammatory markers and nerve function index .In order to observe the change of serum and nerve function, relevant indicators of experimental group patients before operation , postoperative 1, 3, 7, 14 d were compared with those in the control group .Results Serum IL-2 level (5.21 ±0.43)μg/mL of patients with spinal cord injury was significantly lower than the control group , while the serum IL -6 (8.32 ±0.69)pg/mL and IL-8 (8.79 ±0.75)pg/mL, TNF-α(1.25 ±0.12)ng/mL and IL-4 (224.72 ±20.95) ng/mL and IL -10 (19.58 ±1.99) pg/mL and IL -13 (6.32 ±0.67) ng/mL, TGF-β(886.73 ±78.72)pg/mL, NSE (18.77 ±1.77)μg/mL, NGF (386.76 ±28.48)pg/mL and S100B (0.52 ±0.10)ng/mL was significantly higher than those in the control group;and inflammatory factor changes significantly correlated to the nerve function index .Conclusion For the patients with spinal burst fracture , the serum inflammatory factors and neural functions are dynamically changed in those patients companied with spinal cord injury .Therefore , it is of great significance of this study by providing some scientific basis for the clinical diagnosis and treatment for this kind of disease .
