CAJ | 학술논문

目的：探讨尼莫地平治疗创伤性蛛网膜下腔出血的临床疗效。方法回顾性分析创伤性蛛网膜下腔出血患者60例的临床资料。28例患者采用常规治疗为对照组，32例患者在常规治疗的基础上给予尼莫地平治疗为研究组。比较两组患者的临床疗效。结果治疗后，研究组MCA Vp显著快于对照组（P＜0.01），颅内压和脑血管痉挛率以及再出血率均显著低于对照组（P＜0.01）。随访3个月，研究组19例生活自理，7例部分自理，4例重残，2例死亡，生活自理患者比例显著高于对照组，死亡患者比例显著低于对照组（P＜0.05）。两组不良反应差异无统计学意义（P＞0.05）。结论尼莫地平治疗创伤性蛛网膜下腔出血能够显著降低患者的颅内压，降低脑血管痉挛率以及再出血率，改善患者的预后。
목적：탐토니막지평치료창상성주망막하강출혈적림상료효。방법회고성분석창상성주망막하강출혈환자60례적림상자료。28례환자채용상규치료위대조조，32례환자재상규치료적기출상급여니막지평치료위연구조。비교량조환자적림상료효。결과치료후，연구조MCA Vp현저쾌우대조조（P＜0.01），로내압화뇌혈관경련솔이급재출혈솔균현저저우대조조（P＜0.01）。수방3개월，연구조19례생활자리，7례부분자리，4례중잔，2례사망，생활자리환자비례현저고우대조조，사망환자비례현저저우대조조（P＜0.05）。량조불량반응차이무통계학의의（P＞0.05）。결론니막지평치료창상성주망막하강출혈능구현저강저환자적로내압，강저뇌혈관경련솔이급재출혈솔，개선환자적예후。
Objective To discuss clinical efficacy of Nimodipine for traumatic subarachnoid hemorrhage.Methods Clinical data of 60 cases with Nimodipine for traumatic subarachnoid hemorrhage were retrospectively analyzed. Twenty-eight cases were treated by normal treatment as control group, and 32 cases were treated by Nimodipine based on normal treatment as study group. Clinical efficacy of two groups was compared.Results After treatment, MCA Vp of study group was faster than control group(P<0.01), intracranial pressure , cerebral vasospasm rate and rebleeding rate were lower than control group(P<0.01). Following-up for 3 months, of study group, 19 cases were daily living, 7 cases were part of self-care, 4 cases were severe disability, and 2 cases death. Daily living rate of study group was higher than control group, and death rate of study group was lower than control group(P<0.05). Adverse reactions of two groups showed no significant difference(P>0.05).ConclusionNimodipine for traumatic subarachnoid hemorrhage can reduce intracranial pressure, cerebral vasospasm and rebleeding rate, and improve clinical efficacy.