CAJ | 학술논문

目的：探讨2型糖尿病（T2DM）合并急性冠脉综合征（ACS）患者体内氧化应激水平的变化及意义。方法选取本院老年科2012年9月至2014年4月收治的患者89例为研究对象，分成糖尿病对照（DM）组、糖尿病合并冠心病（DM－CAD）组、糖尿病合并急性冠脉综合征（DM－ACS）组，分别检测空腹血糖、糖化血红蛋白（HbA1c）、血脂，血清丙二醛（MDA）、超氧化物歧化酶（SOD）、谷胱甘肽过氧化物酶（GSH－PX）及总抗氧化力（T－AOC）水平。结果三组患者血糖、糖化血红蛋白（HbA1c）、血脂差异均无统计学意义（ P ＞0．05）。 DM－ACS 组血清 MDA 水平较 DM－CAD 组及 DM 对照组明显升高（ P ＜0．05），SOD、GSH－PX、T－AOC 较 DM－CAD 组及 DM 对照组明显降低（ P ＜0．05）。结论2型糖尿病合并急性冠脉综合征患者的氧化应激水平明显升高。
목적：탐토2형당뇨병（T2DM）합병급성관맥종합정（ACS）환자체내양화응격수평적변화급의의。방법선취본원노년과2012년9월지2014년4월수치적환자89례위연구대상，분성당뇨병대조（DM）조、당뇨병합병관심병（DM－CAD）조、당뇨병합병급성관맥종합정（DM－ACS）조，분별검측공복혈당、당화혈홍단백（HbA1c）、혈지，혈청병이철（MDA）、초양화물기화매（SOD）、곡광감태과양화물매（GSH－PX）급총항양화력（T－AOC）수평。결과삼조환자혈당、당화혈홍단백（HbA1c）、혈지차이균무통계학의의（ P ＞0．05）。 DM－ACS 조혈청 MDA 수평교 DM－CAD 조급 DM 대조조명현승고（ P ＜0．05），SOD、GSH－PX、T－AOC 교 DM－CAD 조급 DM 대조조명현강저（ P ＜0．05）。결론2형당뇨병합병급성관맥종합정환자적양화응격수평명현승고。
Objective To investigate the variation of the oxidative stress status in type 2 diabetes mellitus(T2DM)patients with acute coronary syndrome (ACS)and significance.Methods Eighty -nine patients hospitalized in our department from September 2012 to April 2014 were divided into three groups: T2DM control (group DM), T2DM with coronary artery disease(group DM-CAD) and T2DM with acute coronary syndrome (group DM-ACS).Blood glucose,HbA1C,Lipids,serum Malondialdehyde (MDA) level, su-peroxide dismutase(SOD) activity, glutathione peroxidase (GSH-Px) activity and total anti-oxidation capacity(T-AOC) were deter-mined.Results Blood glucose、HbA1C and Lipids were similar in three groups ( P >0.05).Compared to group DM and group DM-CAD, serum MDA levels in group DM-ACS were significantly higher( P <0.05), while SOD、GSH-Px activities and T-AOC were sig-nificantly lower than those in group DM and group DM -CAD( P <0.05).Conclusions The oxidative stress level being significantly increased in T2DM patients with ACS.