CAJ | 학술논문

目的：探讨肝细胞肝癌患者血清中高尔基体蛋白73（GP73）的水平及其临床意义。方法应用 ELISA 法检测75例肝细胞肝癌患者、30例慢性乙肝患者和30例健康对照者 GP73水平。结果肝细胞肝癌组患者血清中 GP73水平[（128．3±33．6）μg／L]均高于慢性乙型肝炎组和健康对照组[（80．3±19．2）μg／L 和（78．3±18．5）μg／L， P ＜0．05]。血清GP73水平与临床分期、肿瘤大小及转移有关（ P ＜0．05）。Ⅰ期患者中 GP73阳性率[60％（9／15）]高于Ⅰ期患者 AFP 阳性率[33％（5／15）， P ＜0．01]。结论血清 GP73在肝细胞肝癌中高表达，可鉴别肝脏的良恶性疾病，其有望成为一个有用的诊断肝细胞肝癌的生物标志。
목적：탐토간세포간암환자혈청중고이기체단백73（GP73）적수평급기림상의의。방법응용 ELISA 법검측75례간세포간암환자、30례만성을간환자화30례건강대조자 GP73수평。결과간세포간암조환자혈청중 GP73수평[（128．3±33．6）μg／L]균고우만성을형간염조화건강대조조[（80．3±19．2）μg／L 화（78．3±18．5）μg／L， P ＜0．05]。혈청GP73수평여림상분기、종류대소급전이유관（ P ＜0．05）。Ⅰ기환자중 GP73양성솔[60％（9／15）]고우Ⅰ기환자 AFP 양성솔[33％（5／15）， P ＜0．01]。결론혈청 GP73재간세포간암중고표체，가감별간장적량악성질병，기유망성위일개유용적진단간세포간암적생물표지。
Objective To investigate the expression of serum Golgi protein 73 in hepatocellular carcinoma(HCC) and analyze the clinical significance.Methods The expression of GP73 was measured by ELISA in 75 HCC ,30 chronic hepatitis and normal con -trols.Results The serum concentrations of GP73 were (128.3 ±33.6)μg/L,(80.3 ±19.2)μg/L and (78.3 ±18.5)μg/L in the HCC, chronic hepatitis patients and normal controls .The serum level of GP73 was significantly higher in HCC than those with chronic hepatitis and healthy controls .GP73 expression was positively correlated with clinical stage , humor size and metastasis.The positive rate of GP73 in stage was 60%,higher than the AFP positive rate(33%).Conclusions The serum level of GP73 is high in HCC and was helpful for distinguishing benign and malignant liver diseases .GP73 can be used as a diagnostic marker for HCC .