CAJ | 학술논문

目的：探讨耳鼻喉神经内分泌癌的临床特点,并对其进行诊断分析。方法回顾性分析5例耳鼻喉神经内分泌癌患者的临床资料,并对其诊断和治疗方法进行临床分析。结果5例患者均行手术和术后放疗及化疗治疗,其中有2例为非典型类癌,1例大细胞神经内分泌癌,2例小细胞神经内分泌癌。经治疗后,患者的肿瘤细胞如细胞角蛋白(CK)、神经元特异性烯醇化酶(NSE)、上皮膜抗原(EMA)、嗜铬蛋白(CgA)、突触蛋白(Syn)等均呈阳性。术后随访以2~4年为期限。结论对耳鼻喉神经内分泌癌进行手术治疗对患者是较合适的治疗方案,早期的准确诊断和综合性治疗是提高本病生存率的关键。
목적：탐토이비후신경내분비암적림상특점,병대기진행진단분석。방법회고성분석5례이비후신경내분비암환자적림상자료,병대기진단화치료방법진행림상분석。결과5례환자균행수술화술후방료급화료치료,기중유2례위비전형유암,1례대세포신경내분비암,2례소세포신경내분비암。경치료후,환자적종류세포여세포각단백(CK)、신경원특이성희순화매(NSE)、상피막항원(EMA)、기락단백(CgA)、돌촉단백(Syn)등균정양성。술후수방이2~4년위기한。결론대이비후신경내분비암진행수술치료대환자시교합괄적치료방안,조기적준학진단화종합성치료시제고본병생존솔적관건。
Objective To explore the clinical features of ear, nose and throat neuroendocrine carcinoma, and to diagnose and treat the disease.Methods The clinical data of 5 patients with ear, nose and throat neuroendocrine carcinoma were analyzed retrospectively. The analysis was also made on the diagnosis and treatment methods for the disease.Results All the 5 cases underwent surgery and postoperative radiotherapy and chemotherapy, and there were 2 cases with atypical carcinoid, 1 case with large cell neuroendocrine carcinoma, and 2 cases with small cell neuroendocrine carcinomas. After the treatment, patients’ cancer cells, such as cytokeratin (CK), neuron specific enolase (NSE), epithelial membrane antigen (EMA), chromogranin (CgA), and synapsin (Syn), were all positive. The follow-up lasted for 2~4 years after treatment.Conclusion Surgery treatment is a suitable method for patients with ear, nose and throat neuroendocrine carcinoma. The Early accurate diagnosis and comprehensive treatment are the keys to improve the survival rate of the disease.