CAJ | 학술논문

目的评价4种新型抗抑郁药物治疗抑郁症的成本－效果。方法将104例符合抑郁症首次发病的患者随机分为4组，分别给予度洛西汀胶囊、文拉法辛缓释胶囊、米氮平片、艾司西酞普兰片。疗效采用17项汉密尔顿抑郁量表（HAMD17）。运用成本－效果法进行分析。结果4组有效率分别为73.08%、69.23%、69.23%、73.08%（P＞0.05），成本分别为768.6元、562.8元、751.2元、751.8元，痊愈的成本－效果比为13.32、11.26、12.36、13.97；有效性的成本－效果比为10.51、8.13、8.25、10.28。结论文拉法辛缓释胶囊组治疗抑郁症成本－效果比更优。
목적평개4충신형항억욱약물치료억욱증적성본－효과。방법장104례부합억욱증수차발병적환자수궤분위4조，분별급여도락서정효낭、문랍법신완석효낭、미담평편、애사서태보란편。료효채용17항한밀이돈억욱량표（HAMD17）。운용성본－효과법진행분석。결과4조유효솔분별위73.08%、69.23%、69.23%、73.08%（P＞0.05），성본분별위768.6원、562.8원、751.2원、751.8원，전유적성본－효과비위13.32、11.26、12.36、13.97；유효성적성본－효과비위10.51、8.13、8.25、10.28。결논문랍법신완석효낭조치료억욱증성본－효과비경우。
Objective To evaluate the cost-effectiveness of 4 new antidepressants for treatment of depression. Method 104 patients, who met the criteria of first-onset of depressive disorder, were randomly assigned into 4 groups and treated with duloxetine capsules, venlafaxine sustained-release capsules, mirtazapine tablets, escitalopram tablets respectively for 6 weeks. The Hamilton Depressive Scale (HAMD17) was adopted to assess efficacy and cost-effectiveness analysis was also applied. Results The efficient rate of four groups was 73.08%, 69.23%, 69.23%and 73.08%(P>0.05) respectively, and the costs were 768.6 Yuan, 562.8 Yuan, 751.2 Yuan and 751.8 Yuan. The cost-effectiveness ratio for healing was 13.32, 11.26, 12.36, and 13.97 and for efficacy was 10.51, 8.13, 8.25, and 10.28. Conclusion The regimen of venlafaxine sustained-release capsule is superior in terms of the cost-effectiveness ratios.