浙江化工
浙江化工
절강화공
ZHEJIANG CHEMICAL INDUSTRY
2014年
11期
16-18
,共3页
4-雄烯二酮%5α-氯-6β-羟基-雄甾-3,17-二酮%中间体
4-雄烯二酮%5α-氯-6β-羥基-雄甾-3,17-二酮%中間體
4-웅희이동%5α-록-6β-간기-웅치-3,17-이동%중간체
4-androstenedione%5α-chloro-6β-hydroxy-androst-3,17-dion%intermediate
以4-雄烯二酮为原料，经羰基保护、双键卤羟化、水解脱保护三步反应合成了5α-氯-6β-羟基-雄甾-3,17-二酮。讨论了保护试剂、催化剂、卤羟化试剂、反应温度等对实验结果的影响，得出了较佳工艺条件，三步总收率达到88%。
以4-雄烯二酮為原料，經羰基保護、雙鍵滷羥化、水解脫保護三步反應閤成瞭5α-氯-6β-羥基-雄甾-3,17-二酮。討論瞭保護試劑、催化劑、滷羥化試劑、反應溫度等對實驗結果的影響，得齣瞭較佳工藝條件，三步總收率達到88%。
이4-웅희이동위원료，경탄기보호、쌍건서간화、수해탈보호삼보반응합성료5α-록-6β-간기-웅치-3,17-이동。토론료보호시제、최화제、서간화시제、반응온도등대실험결과적영향，득출료교가공예조건，삼보총수솔체도88%。
Using 4-androstenedione as raw material, 5α-chloro-6β-hydroxy-androst-3,17-dione was synthesized via carbonyl protection, halogen hydroxylation of double bound and hydrolysis deprotection. The effect of protecting agent, catalyst, halogen hydroxylation agent and temperature were discussed. A better technological condition was obtained with the total yields of 88%.
