CAJ | 학술논문

靶向药物由于其药效好、特异性强且毒副作用小，已成为全球新药研发的热点。配体与大分子之间的相互作用在寻找先导化合物的过程中至关重要。亲和筛选可以解决传统筛选技术过高的假阳性和假阴性的概率及逐一测定化合物活性的限制等问题，相比传统的生物测定有明显的优势。
파향약물유우기약효호、특이성강차독부작용소，이성위전구신약연발적열점。배체여대분자지간적상호작용재심조선도화합물적과정중지관중요。친화사선가이해결전통사선기술과고적가양성화가음성적개솔급축일측정화합물활성적한제등문제，상비전통적생물측정유명현적우세。
Target-based drugs have become a global hotspot as their good efficacy,high specificity and low toxicity. Interactions between ligands and molecules are essential to discover lead compounds in the screening process. Affinity screening has obvious advantages compared to traditional methods. A lot of drug candidates or fragments could be tested simultaneously with low false positive and false negative rate.