CAJ | 학술논문

以甲醇与丙二腈为主要原料，在无水甲苯的氯化氢体系中发生亲核加成反应合成1，3-二甲氧基丙二亚胺盐酸盐；碱中和后与单腈胺反应生成3-氨基-3-甲氧基-N-腈基-2-丙咪；甲苯中回流环合生成2-氨基-4，6-二甲氧基嘧啶。采用单因素法考察了反应溶剂、反应时间、反应温度等对产品收率的影响。得到了合成目标产物的最佳条件，在此条件下目标产品的最终收率为75％（以丙二腈记）。
이갑순여병이정위주요원료，재무수갑분적록화경체계중발생친핵가성반응합성1，3-이갑양기병이아알염산염；감중화후여단정알반응생성3-안기-3-갑양기-N-정기-2-병미；갑분중회류배합생성2-안기-4，6-이갑양기밀정。채용단인소법고찰료반응용제、반응시간、반응온도등대산품수솔적영향。득도료합성목표산물적최가조건，재차조건하목표산품적최종수솔위75％（이병이정기）。
2-amino-4,6-dimethoxy pyrimidine was prepared by using methyol and malononitrile as main materials in the following steps. 1,3 -dimethoxy propyleneimine hydrochloride was firstly made in anhydrous toluene,then reacted with cyanamide to give 3 -amino -3 -methoxy -N - nitrile propionamidine,finally cyclized in toluene to give the target product. Different reaction conditions such as reaction solvent,time and temperature were discussed. The best yields can reach up to 75% at the optional conditions.