首都医科大学学报
首都醫科大學學報
수도의과대학학보
JOURNAL OF CAPITAL UNIVERSITY OF MEDICAL SCIENCES
2014年
6期
790-797
,共8页
眼附属器%淋巴造血组织增生性疾病%结外黏膜相关组织边缘区 B 细胞淋巴瘤%IgG4 相关性疾病%临床病理
眼附屬器%淋巴造血組織增生性疾病%結外黏膜相關組織邊緣區 B 細胞淋巴瘤%IgG4 相關性疾病%臨床病理
안부속기%림파조혈조직증생성질병%결외점막상관조직변연구 B 세포림파류%IgG4 상관성질병%림상병리
orbital and ocular adnexal%lymphoid and hemopoietic tissue proliferation disease%extraocular marginal zone lymphoma of mucosa-associated lymphoid tissue type%IgG4-related disease%clinicopathology
目的：探讨眼附属器淋巴造血组织增生性疾病的临床病理学特征。方法回顾性分析210例首都医科大学附属北京同仁医院眼附属器淋巴造血组织增生性疾病患者的临床资料和临床病理资料。结果①该组眼附属器淋巴造血组织增生性疾病中最常见的是非霍奇金淋巴瘤(100例,47.6%),其次为炎性假瘤(45例,21.4%)和良性淋巴上皮病变(Mikuliczs 病,41例,19.5%)。②该组病变部分类型在发病年龄和性别上有特点,组织病理学上的表现有交叉。③该部位非霍奇金淋巴瘤中最常见的为结外黏膜相关组织边缘区 B 细胞淋巴瘤(74例),眼附属器的结外黏膜相关组织边缘区 B 细胞淋巴瘤有其不同于其他解剖部位的该肿瘤的特点。④免疫组织化学染色在该部位淋巴造血组织增生性疾病的诊断和鉴别诊断中有非常重要的作用。⑤眼附属器的 IgG4相关性疾病(10例)的诊断和临床病理表现有其独有的特征。结论眼附属器淋巴造血组织增生性疾病是一类比较常见的疾病,其在发病年龄、性别等临床表现和组织学类型上都具有明显的临床病理学特征,掌握这些对临床病理诊断将提供较大的帮助。
目的：探討眼附屬器淋巴造血組織增生性疾病的臨床病理學特徵。方法迴顧性分析210例首都醫科大學附屬北京同仁醫院眼附屬器淋巴造血組織增生性疾病患者的臨床資料和臨床病理資料。結果①該組眼附屬器淋巴造血組織增生性疾病中最常見的是非霍奇金淋巴瘤(100例,47.6%),其次為炎性假瘤(45例,21.4%)和良性淋巴上皮病變(Mikuliczs 病,41例,19.5%)。②該組病變部分類型在髮病年齡和性彆上有特點,組織病理學上的錶現有交扠。③該部位非霍奇金淋巴瘤中最常見的為結外黏膜相關組織邊緣區 B 細胞淋巴瘤(74例),眼附屬器的結外黏膜相關組織邊緣區 B 細胞淋巴瘤有其不同于其他解剖部位的該腫瘤的特點。④免疫組織化學染色在該部位淋巴造血組織增生性疾病的診斷和鑒彆診斷中有非常重要的作用。⑤眼附屬器的 IgG4相關性疾病(10例)的診斷和臨床病理錶現有其獨有的特徵。結論眼附屬器淋巴造血組織增生性疾病是一類比較常見的疾病,其在髮病年齡、性彆等臨床錶現和組織學類型上都具有明顯的臨床病理學特徵,掌握這些對臨床病理診斷將提供較大的幫助。
목적：탐토안부속기림파조혈조직증생성질병적림상병이학특정。방법회고성분석210례수도의과대학부속북경동인의원안부속기림파조혈조직증생성질병환자적림상자료화림상병리자료。결과①해조안부속기림파조혈조직증생성질병중최상견적시비곽기금림파류(100례,47.6%),기차위염성가류(45례,21.4%)화량성림파상피병변(Mikuliczs 병,41례,19.5%)。②해조병변부분류형재발병년령화성별상유특점,조직병이학상적표현유교차。③해부위비곽기금림파류중최상견적위결외점막상관조직변연구 B 세포림파류(74례),안부속기적결외점막상관조직변연구 B 세포림파류유기불동우기타해부부위적해종류적특점。④면역조직화학염색재해부위림파조혈조직증생성질병적진단화감별진단중유비상중요적작용。⑤안부속기적 IgG4상관성질병(10례)적진단화림상병리표현유기독유적특정。결론안부속기림파조혈조직증생성질병시일류비교상견적질병,기재발병년령、성별등림상표현화조직학류형상도구유명현적림상병이학특정,장악저사대림상병리진단장제공교대적방조。
Objective To study the clinicopathologic characteristics of lymphoid and hemopoietic tissue proliferation disease in orbital and ocular adnexal. Methods Clinical manifestations and the characteristics of clinicopathology were analyzed retrospectively in two hundreds and ten patients suffering from lymphoid and hemopoietic tissue proliferation in orbital and ocular adnexal. Results The most common histologic type in orbital and ocular adnexa is primary extraocular non-Hodgkin's lymphoma, secondly was Mikuliczs disease and inflammatory pseudotumor. There is a characteristic in age and gender among the various types of this group, and there is an overlap in clinicopathologic characteristics. The most common histologic subtype was extraocular marginal zone lymphoma of mucosa-associated lymphoid tissue type in extraocular non-Hodgkin' s lymphoma, which accounted for 74. 0% (74 / 100 cases) of cases. The extraocular marginal zone lymphoma of mucosa-associated lymphoid tissue type has different traits from that at other sites. Immunohistochemical staining is very important to the diagnosis and differential diagnosis for lymphoid and hemopoietic tissue proliferation disease in this site. The unique feature in diagnosis and clinicopathology is obvious to IgG4-related disease of this site. Conclusion We conclude that lymphoid and hemopoietic tissue proliferation disease in orbital and ocular adnexal is common among patients. There is a characteristic in age, gender and histologic subtype, which is helpful to understand these characteristics for pathological diagnosis.
