CAJ | 학술논문

目的：分析HIV／AIDS患者抗病毒治疗前后的心电图变化，探讨抗病毒药物对心电活动的影响。方法将130例HIV／AIDS患者按抗病毒治疗时间的长短分为3组，抗病毒治疗时间在1～3年的为A组，4～6年的为B组，7～10年的为C组。对3组患者治疗前后的常规心电图进行比较分析。结果比较抗病毒治疗前后正常心电图、窦性心动过速的发生率及C组异常心电图发生率，差异有统计学意义（ P＜0．05）。 A、B两组异常心电图发生率及ST-T改变、窦性心动过缓、心电轴左偏、左室高电压的发生率抗病毒治疗后较治疗前有所升高，但差异无统计学意义（ P＞0．05）。结论 HIV病毒及高强度的抗病毒治疗会影响心电活动，与患者病程进展及抗病毒治疗时间密切相关。
목적：분석HIV／AIDS환자항병독치료전후적심전도변화，탐토항병독약물대심전활동적영향。방법장130례HIV／AIDS환자안항병독치료시간적장단분위3조，항병독치료시간재1～3년적위A조，4～6년적위B조，7～10년적위C조。대3조환자치료전후적상규심전도진행비교분석。결과비교항병독치료전후정상심전도、두성심동과속적발생솔급C조이상심전도발생솔，차이유통계학의의（ P＜0．05）。 A、B량조이상심전도발생솔급ST-T개변、두성심동과완、심전축좌편、좌실고전압적발생솔항병독치료후교치료전유소승고，단차이무통계학의의（ P＞0．05）。결론 HIV병독급고강도적항병독치료회영향심전활동，여환자병정진전급항병독치료시간밀절상관。
Objective To analyze the ECG changes of HIV/AIDS patients before and after anti-viral therapy , and to explore the impact of antiviral drugs on heart's electrical activity .Methods The enrolled 130 HIV/AIDS patients were divided into three groups according to the duration of an-tiviral therapy:group A(1-3 years of antiviral therapy), group B(4-6 years of antiviral thera-py), amd group C(7-10 years of antiviral therapy).Routine electrocardiograms(ECGs) before and after the treatment were comparatively analyzed .Results Before and after antiviral therapy , the differences of incidence rates of normal ECG , sinus tachycardia , and abnormal ECG in group C were statistically significant ( P<0 .05 ) .In group A and group B , after antiviral therapy , the incidence rates of abnormal ECG , ST-T changes , sinus bradycardia , left axis deviation , and left ventricular high voltage all increased than before , however , without statistically significant differences ( P >0 .05 ) .Conclusion HIV and high-intensive antiviral therapy obviously damage heart's electrical activity, which is closely related to progression of the disease and the duration of antiviral therapy .