江苏实用心电学杂志
江囌實用心電學雜誌
강소실용심전학잡지
JOURNAL OF PRACTICAL ELECTROCARDIOLOGYJS
2014年
6期
405-410
,共6页
竺英祺%沈仲元%Shin Lin%闫世彪%陈洪波%刘仁光
竺英祺%瀋仲元%Shin Lin%閆世彪%陳洪波%劉仁光
축영기%침중원%Shin Lin%염세표%진홍파%류인광
心搏频率%呼吸频率%通气量%自主神经系统
心搏頻率%呼吸頻率%通氣量%自主神經繫統
심박빈솔%호흡빈솔%통기량%자주신경계통
heart rate%respiratory rate%tidal volume%autonomic nervous system
目的:观察呼吸频率和潮气量变化对心率的影响。方法建立兔机械通气模型,通过呼吸机调节呼吸参数,在全身麻醉下行呼吸机机械通气。参数调节:潮气量恒定10 mL/kg ,呼吸频率40、50、60次/min;呼吸频率恒定50次/min,潮气量8、10、12 mL/kg。动物分组:健康日本大耳白兔72只,其中药物阻滞组30只,分为单纯呼吸组、阿托品组和艾司洛尔组,每组10只;手术切断组42只,分为迷走神经组和交感神经组,每组21只。结果①药物阻滞组中,3个组在呼吸频率40次/min时的心率,要低于呼吸频率50、60次/min时的心率,差异有统计学意义(P<0.01)。②手术切断组中,迷走组和交感组无论在自主神经分离前还是在切断自主神经后,呼吸频率40次/min时的心率,要低于呼吸频率50、60次/min时的心率,差异有统计学意义( P<0.01,P<0.05)。③药物阻滞组中,3个组在潮气量8 mL/kg时的心率,要低于10、12 mL/kg的心率,差异有统计学意义( P<0.01)。④手术切断组中,迷走组和交感组无论在自主神经分离前还是在切断自主神经后,在潮气量8 mL/kg时的心率,要低于10、12 mL/kg的心率,差异有统计学意义(P<0.01,P<0.05)。结论减慢呼吸频率时与心率减慢一致,与HRV频谱成分理论意义相符。无论在正常情况下还是自主神经被阻滞或切断,减少通气量时与心率减慢一致,还需要进一步的研究。
目的:觀察呼吸頻率和潮氣量變化對心率的影響。方法建立兔機械通氣模型,通過呼吸機調節呼吸參數,在全身痳醉下行呼吸機機械通氣。參數調節:潮氣量恆定10 mL/kg ,呼吸頻率40、50、60次/min;呼吸頻率恆定50次/min,潮氣量8、10、12 mL/kg。動物分組:健康日本大耳白兔72隻,其中藥物阻滯組30隻,分為單純呼吸組、阿託品組和艾司洛爾組,每組10隻;手術切斷組42隻,分為迷走神經組和交感神經組,每組21隻。結果①藥物阻滯組中,3箇組在呼吸頻率40次/min時的心率,要低于呼吸頻率50、60次/min時的心率,差異有統計學意義(P<0.01)。②手術切斷組中,迷走組和交感組無論在自主神經分離前還是在切斷自主神經後,呼吸頻率40次/min時的心率,要低于呼吸頻率50、60次/min時的心率,差異有統計學意義( P<0.01,P<0.05)。③藥物阻滯組中,3箇組在潮氣量8 mL/kg時的心率,要低于10、12 mL/kg的心率,差異有統計學意義( P<0.01)。④手術切斷組中,迷走組和交感組無論在自主神經分離前還是在切斷自主神經後,在潮氣量8 mL/kg時的心率,要低于10、12 mL/kg的心率,差異有統計學意義(P<0.01,P<0.05)。結論減慢呼吸頻率時與心率減慢一緻,與HRV頻譜成分理論意義相符。無論在正常情況下還是自主神經被阻滯或切斷,減少通氣量時與心率減慢一緻,還需要進一步的研究。
목적:관찰호흡빈솔화조기량변화대심솔적영향。방법건립토궤계통기모형,통과호흡궤조절호흡삼수,재전신마취하행호흡궤궤계통기。삼수조절:조기량항정10 mL/kg ,호흡빈솔40、50、60차/min;호흡빈솔항정50차/min,조기량8、10、12 mL/kg。동물분조:건강일본대이백토72지,기중약물조체조30지,분위단순호흡조、아탁품조화애사락이조,매조10지;수술절단조42지,분위미주신경조화교감신경조,매조21지。결과①약물조체조중,3개조재호흡빈솔40차/min시적심솔,요저우호흡빈솔50、60차/min시적심솔,차이유통계학의의(P<0.01)。②수술절단조중,미주조화교감조무론재자주신경분리전환시재절단자주신경후,호흡빈솔40차/min시적심솔,요저우호흡빈솔50、60차/min시적심솔,차이유통계학의의( P<0.01,P<0.05)。③약물조체조중,3개조재조기량8 mL/kg시적심솔,요저우10、12 mL/kg적심솔,차이유통계학의의( P<0.01)。④수술절단조중,미주조화교감조무론재자주신경분리전환시재절단자주신경후,재조기량8 mL/kg시적심솔,요저우10、12 mL/kg적심솔,차이유통계학의의(P<0.01,P<0.05)。결론감만호흡빈솔시여심솔감만일치,여HRV빈보성분이론의의상부。무론재정상정황하환시자주신경피조체혹절단,감소통기량시여심솔감만일치,환수요진일보적연구。
Objective To observe effects of the changes of respiratory frequency ( RF) and tidal volume on rabbits'heart rate .Methods Mechanical ventilation model was constructed for rabbits and mechanical ventilation was performed under general anesthesia , with respiratory parameters reg-ulated by breathing machine .Respiratory parameters regulation:( i) the tidal volume was constant at 10 mL/kg while respiratory frequency was set 40, 50, and 60 beats/min separately;(ii) The re-spiratory frequency was constant at 50 beats/min while tidal volume was set 8, 10, and 12 mL/kg separately .Experimental animal grouping:72 healthy rabbits were divided into two major groups , medicine group(30 rabbits) and operation group (42 rabbits).The former was divided into three subgroups(no medicine, atropine, esmolol) further, each with 10 rabbits.The latter was divided into two subgroups ( pneumogastric nerve and sympathetic nerve ) further, each with 21 rabbits .Re-sults ( i) In medicine group , the heart rates of rabbits in all the three subgroups at a RF of 40 beats/min were significantly lower than those at a RF of 50 or 60 beats/min, and the differences were statistically significant(P<0.01).(ii) In operation group, when RF was 40 beats/min, the heart rates of rabbits in pneumogastric nerve subgroup and sympathetic nerve subgroup were signifi -cantly lower than those at a RF of 50 or 60 beats/min, no matter before or after separation of auto-nomic nerve, and the differences were statistically significant (P<0.01, P<0.05).(iii) In medi-cine group, when tidal volume was 8 mL/kg, the heart rates of rabbits in the three subgroups were all lower than those when tidal volume was 10 or 12 mL/kg, and the differences were statistically significant(P<0.01).(iv) In operation group, when tidal volume was 8 mL/kg, the heart rates of rabbits in pneumogastric nerve subgroup and sympathetic nerve subgroup were significantly lower than those when tidal volume was 10 or 12 mL/kg, no matter before or after separation of autonomic nerve, and the differences were statistically significant (P<0.01,P<0.05).Conclusion The sl-owdown of respiratory rate is in accordance with the slowdown of heart rate , which is in line with the HRV spectral composition theory .No matter when it is under normal condition or when automatic nervous system is blocked ( both by medicine and by operation ) , the decrease of tidal volume is in correspondence with the slowdown of heart rate .However the reasons for that requires further inves-tigation.