CAJ | 학술논문

目的：观察呼吸频率和潮气量变化对心率的影响。方法建立兔机械通气模型，通过呼吸机调节呼吸参数，在全身麻醉下行呼吸机机械通气。参数调节：潮气量恒定10 mL／kg ，呼吸频率40、50、60次／min；呼吸频率恒定50次／min，潮气量8、10、12 mL／kg。动物分组：健康日本大耳白兔72只，其中药物阻滞组30只，分为单纯呼吸组、阿托品组和艾司洛尔组，每组10只；手术切断组42只，分为迷走神经组和交感神经组，每组21只。结果①药物阻滞组中，3个组在呼吸频率40次／min时的心率，要低于呼吸频率50、60次／min时的心率，差异有统计学意义（P＜0．01）。②手术切断组中，迷走组和交感组无论在自主神经分离前还是在切断自主神经后，呼吸频率40次／min时的心率，要低于呼吸频率50、60次／min时的心率，差异有统计学意义（ P＜0．01，P＜0．05）。③药物阻滞组中，3个组在潮气量8 mL／kg时的心率，要低于10、12 mL／kg的心率，差异有统计学意义（ P＜0．01）。④手术切断组中，迷走组和交感组无论在自主神经分离前还是在切断自主神经后，在潮气量8 mL／kg时的心率，要低于10、12 mL／kg的心率，差异有统计学意义（P＜0．01，P＜0．05）。结论减慢呼吸频率时与心率减慢一致，与HRV频谱成分理论意义相符。无论在正常情况下还是自主神经被阻滞或切断，减少通气量时与心率减慢一致，还需要进一步的研究。
목적：관찰호흡빈솔화조기량변화대심솔적영향。방법건립토궤계통기모형，통과호흡궤조절호흡삼수，재전신마취하행호흡궤궤계통기。삼수조절：조기량항정10 mL／kg ，호흡빈솔40、50、60차／min；호흡빈솔항정50차／min，조기량8、10、12 mL／kg。동물분조：건강일본대이백토72지，기중약물조체조30지，분위단순호흡조、아탁품조화애사락이조，매조10지；수술절단조42지，분위미주신경조화교감신경조，매조21지。결과①약물조체조중，3개조재호흡빈솔40차／min시적심솔，요저우호흡빈솔50、60차／min시적심솔，차이유통계학의의（P＜0．01）。②수술절단조중，미주조화교감조무론재자주신경분리전환시재절단자주신경후，호흡빈솔40차／min시적심솔，요저우호흡빈솔50、60차／min시적심솔，차이유통계학의의（ P＜0．01，P＜0．05）。③약물조체조중，3개조재조기량8 mL／kg시적심솔，요저우10、12 mL／kg적심솔，차이유통계학의의（ P＜0．01）。④수술절단조중，미주조화교감조무론재자주신경분리전환시재절단자주신경후，재조기량8 mL／kg시적심솔，요저우10、12 mL／kg적심솔，차이유통계학의의（P＜0．01，P＜0．05）。결론감만호흡빈솔시여심솔감만일치，여HRV빈보성분이론의의상부。무론재정상정황하환시자주신경피조체혹절단，감소통기량시여심솔감만일치，환수요진일보적연구。
Objective To observe effects of the changes of respiratory frequency ( RF) and tidal volume on rabbits'heart rate .Methods Mechanical ventilation model was constructed for rabbits and mechanical ventilation was performed under general anesthesia , with respiratory parameters reg-ulated by breathing machine .Respiratory parameters regulation:( i) the tidal volume was constant at 10 mL/kg while respiratory frequency was set 40, 50, and 60 beats/min separately;(ii) The re-spiratory frequency was constant at 50 beats/min while tidal volume was set 8, 10, and 12 mL/kg separately .Experimental animal grouping:72 healthy rabbits were divided into two major groups , medicine group(30 rabbits) and operation group (42 rabbits).The former was divided into three subgroups(no medicine, atropine, esmolol) further, each with 10 rabbits.The latter was divided into two subgroups ( pneumogastric nerve and sympathetic nerve ) further, each with 21 rabbits .Re-sults ( i) In medicine group , the heart rates of rabbits in all the three subgroups at a RF of 40 beats/min were significantly lower than those at a RF of 50 or 60 beats/min, and the differences were statistically significant(P<0.01).(ii) In operation group, when RF was 40 beats/min, the heart rates of rabbits in pneumogastric nerve subgroup and sympathetic nerve subgroup were signifi -cantly lower than those at a RF of 50 or 60 beats/min, no matter before or after separation of auto-nomic nerve, and the differences were statistically significant (P<0.01, P<0.05).(iii) In medi-cine group, when tidal volume was 8 mL/kg, the heart rates of rabbits in the three subgroups were all lower than those when tidal volume was 10 or 12 mL/kg, and the differences were statistically significant(P<0.01).(iv) In operation group, when tidal volume was 8 mL/kg, the heart rates of rabbits in pneumogastric nerve subgroup and sympathetic nerve subgroup were significantly lower than those when tidal volume was 10 or 12 mL/kg, no matter before or after separation of autonomic nerve, and the differences were statistically significant (P<0.01,P<0.05).Conclusion The sl-owdown of respiratory rate is in accordance with the slowdown of heart rate , which is in line with the HRV spectral composition theory .No matter when it is under normal condition or when automatic nervous system is blocked ( both by medicine and by operation ) , the decrease of tidal volume is in correspondence with the slowdown of heart rate .However the reasons for that requires further inves-tigation.