CAJ | 학술논문

磷脂酰肌醇信号通路参与许多的癌症和其他疾病发生发展。该通路中存在多个肿瘤相关基因，其中抑癌基因 PTEN、癌基因 PI 3 K 是被广泛研究的两个基因。最近这条通路中的另一个磷脂酰磷酸酶，磷脂酰肌醇4-磷酸酶Ⅱ型（ INPP 4 B ），被证实是一个潜在的肿瘤抑制基因，其在前列腺癌、乳腺癌中低表达或突变，与该疾病的发生、预后相关。该文重点阐述了 INPP 4 B 的分子结构和功能，及其介导的 Akt-mTOR 信号传导通路，与 PTEN 的协同作用及与几种肿瘤的相关性，并探讨 INPP 4 B 在细胞核内维护基因组稳定性的潜在作用。总之，对 INPP 4 B 的深入研究不仅为磷脂酰肌醇信号调控肿瘤发生提供了新机制，而且为抗肿瘤药物研究提供了有价值的分子靶点。
린지선기순신호통로삼여허다적암증화기타질병발생발전。해통로중존재다개종류상관기인，기중억암기인 PTEN、암기인 PI 3 K 시피엄범연구적량개기인。최근저조통로중적령일개린지선린산매，린지선기순4-린산매Ⅱ형（ INPP 4 B ），피증실시일개잠재적종류억제기인，기재전렬선암、유선암중저표체혹돌변，여해질병적발생、예후상관。해문중점천술료 INPP 4 B 적분자결구화공능，급기개도적 Akt-mTOR 신호전도통로，여 PTEN 적협동작용급여궤충종류적상관성，병탐토 INPP 4 B 재세포핵내유호기인조은정성적잠재작용。총지，대 INPP 4 B 적심입연구불부위린지선기순신호조공종류발생제공료신궤제，이차위항종류약물연구제공료유개치적분자파점。
Phosphatidyl inositol signaling pathway is involved in the occurrence and development of many cancers and other diseases .The tumor suppressor PTEN and oncogene PI 3 K are the best known tumor related genes in this signaling pathway .Recently , another lipid phosphatase , Inositol polyphosphate 4-phosphatase type Ⅱ ( INPP 4 B ) , has emerged as a potential tumor suppressor in prostate , breast , and other malignancies .Mutation or low expression of INPP 4 B has been closely related to the poor prognosis of these cancers .In this review , we focused on the structure and enzymatic functions of INPP 4 B , its in-volved Akt-mTOR signaling pathway , connection to PTEN , correlation with the development of several tumors , as well as its potential nuclear role in maintaining genomic stability .Taken together , the new ad-vances of INPP 4 B research will shed new light no tumorigenic mechanisms underlying the biosynthesis of inositol phosphate , and will offer novel potential therapeutic targets for cancer treatment .