CAJ | 학술논문

大量研究表明，不利的宫内环境，尤其是孕期营养摄入不足或过多均能影响胎儿的正常发育和代谢，并通过与胎儿遗传因素发生交互作用，改变与胎儿能量代谢相关的基因表型，增加子代出生后罹患肥胖、胰岛素抵抗和2型糖尿病的风险。研究还发现，孕期营养失衡主要是通过 DNA 甲基化、组蛋白修饰和 microRNA 调控等表观遗传学机制影响胎儿发育和代谢，对2型糖尿病的发生有深远影响。该文综述了孕期营养失衡与2型糖尿病的最新文献，期望为孕产妇膳食营养和预防2型糖尿病的发生提供科学的理论依据。
대량연구표명，불리적궁내배경，우기시잉기영양섭입불족혹과다균능영향태인적정상발육화대사，병통과여태인유전인소발생교호작용，개변여태인능량대사상관적기인표형，증가자대출생후리환비반、이도소저항화2형당뇨병적풍험。연구환발현，잉기영양실형주요시통과 DNA 갑기화、조단백수식화 microRNA 조공등표관유전학궤제영향태인발육화대사，대2형당뇨병적발생유심원영향。해문종술료잉기영양실형여2형당뇨병적최신문헌，기망위잉산부선식영양화예방2형당뇨병적발생제공과학적이론의거。
A number of studies showed adverse intrauterine environment , especially inadequate or excessive intake of nutrients in pregnancy are likely to affect the normal development of fetus , change the genes phenotype associated with fetal energy metabolism through the interaction with fetal genetic factors , and lead to increased risks of developing obesity , insulin resistance and type 2 diabetes in adult hood . Studies also indicated that eip-genetic factors such as DNA methylation , histone modification and the miR-NA expression would have far-reaching impacts on fetal development , energy metabolism and type 2 diabe-tes .This review summarized recent literatures about the impacts of nutritional imbalance during pregnancy on the development of type Ⅱ diabetes .Expect to provide scientific advices for maternal dietary intake and prevention of type 2 diabetes .