CAJ | 학술논문

凋亡细胞清除缺陷在自身免疫性疾病的发病中有重要作用，C反应蛋白（ CRP）与死亡或受损细胞上的磷酸胆碱及相关分子结合，具有重要免疫调节功能。 CRP作为可溶性调理素通过活化补体和（或）与免疫球蛋白受体FcγR结合，促进病原体和凋亡细胞或核抗原清除，防止自身免疫病的发生，因此CRP在自身免疫和炎性疾病中有重要作用，临床上CRP水平也是一个敏感的自身免疫和炎性反应指标，可用于活动性自身免疫病的评估和诊断。
조망세포청제결함재자신면역성질병적발병중유중요작용，C반응단백（ CRP）여사망혹수손세포상적린산담감급상관분자결합，구유중요면역조절공능。 CRP작위가용성조리소통과활화보체화（혹）여면역구단백수체FcγR결합，촉진병원체화조망세포혹핵항원청제，방지자신면역병적발생，인차CRP재자신면역화염성질병중유중요작용，림상상CRP수평야시일개민감적자신면역화염성반응지표，가용우활동성자신면역병적평고화진단。
Impaired clearance of apoptotic cells is important in the pathogenesis of autoimmune disease.C-reactive protein (CRP) is an acute phase protein that plays a major role in the regulation of the autoimmune and inflammatory response .CRP has a role in the clearance of bacteria and dying and altered cells through binding to phosphocholine and might also have more complex immunomodulatory functions . CRP function as opsonins for pathogens and dying and apoptotic cells through activation of the complement pathway and through binding to Fcγreceptors , and is associated with the clearance of apoptotic cells and nuclear antigen , thus becoming a protective molecule against pathogenic autoimmune responses in general . Measurement of serum CRP level is in widespread clinical use as a sensitive marker of inflammation and autoimmune disease , particularly in relation to the use of the CRP-based disease activity score in the evaluation of rheumatoid disease.