中国循环杂志
中國循環雜誌
중국순배잡지
CHINESE CIRCULATION JOURNAL
2014年
11期
888-890
,共3页
缬沙坦%阵发性心房颤动%高敏C反应蛋白%白细胞介素-6
纈沙坦%陣髮性心房顫動%高敏C反應蛋白%白細胞介素-6
힐사탄%진발성심방전동%고민C반응단백%백세포개소-6
Valsartan%Paroxysmal atrial ifbrillation%High sensitive C-reactive protein%Interleukin-6
目的：探讨缬沙坦对高血压并阵发性心房颤动（PAF）患者体内炎症因子的干预作用。<br> 方法：选择高血压合并PAF已转复窦性心律患者60例，随机分为缬沙坦组30例和对照组30例，对照组口服非洛地平缓释片，缬沙坦组口服缬沙坦胶囊，疗程为6个月。另选取同期健康体检正常者3O例为正常组。于治疗前后分别检测高敏C反应蛋白（hs-CRP）、白细胞介素-6（IL-6）、左心房舒张末期内径（LADd）及心房颤动复律后窦性心律的维持率。<br> 结果：对照组、缬沙坦组两组患者hs-CRP、IL-6、LADd均显著高于正常组（P均<0.01），治疗6个月后，两组患者hs-CRP、IL-6、LADd均较治疗前显著下降（P<0.O1），但缬沙坦组更显著（P均<0.01）。缬沙坦组窦性心律维持率显著高于对照组（P<0.05）。<br> 结论：缬沙坦可能通过抑制炎症反应改善心房结构重构，从而更好的维持高血压合并PAF患者复律后的窦性心律，其抗炎作用可能独立于其降压作用。
目的：探討纈沙坦對高血壓併陣髮性心房顫動（PAF）患者體內炎癥因子的榦預作用。<br> 方法：選擇高血壓閤併PAF已轉複竇性心律患者60例，隨機分為纈沙坦組30例和對照組30例，對照組口服非洛地平緩釋片，纈沙坦組口服纈沙坦膠囊，療程為6箇月。另選取同期健康體檢正常者3O例為正常組。于治療前後分彆檢測高敏C反應蛋白（hs-CRP）、白細胞介素-6（IL-6）、左心房舒張末期內徑（LADd）及心房顫動複律後竇性心律的維持率。<br> 結果：對照組、纈沙坦組兩組患者hs-CRP、IL-6、LADd均顯著高于正常組（P均<0.01），治療6箇月後，兩組患者hs-CRP、IL-6、LADd均較治療前顯著下降（P<0.O1），但纈沙坦組更顯著（P均<0.01）。纈沙坦組竇性心律維持率顯著高于對照組（P<0.05）。<br> 結論：纈沙坦可能通過抑製炎癥反應改善心房結構重構，從而更好的維持高血壓閤併PAF患者複律後的竇性心律，其抗炎作用可能獨立于其降壓作用。
목적：탐토힐사탄대고혈압병진발성심방전동（PAF）환자체내염증인자적간예작용。<br> 방법：선택고혈압합병PAF이전복두성심률환자60례，수궤분위힐사탄조30례화대조조30례，대조조구복비락지평완석편，힐사탄조구복힐사탄효낭，료정위6개월。령선취동기건강체검정상자3O례위정상조。우치료전후분별검측고민C반응단백（hs-CRP）、백세포개소-6（IL-6）、좌심방서장말기내경（LADd）급심방전동복률후두성심률적유지솔。<br> 결과：대조조、힐사탄조량조환자hs-CRP、IL-6、LADd균현저고우정상조（P균<0.01），치료6개월후，량조환자hs-CRP、IL-6、LADd균교치료전현저하강（P<0.O1），단힐사탄조경현저（P균<0.01）。힐사탄조두성심률유지솔현저고우대조조（P<0.05）。<br> 결론：힐사탄가능통과억제염증반응개선심방결구중구，종이경호적유지고혈압합병PAF환자복률후적두성심률，기항염작용가능독립우기강압작용。
Objective: To explore the effect of valsartan on inflammatory cytokines in patients with hypertension combining paroxysmal atrial ifbrillation (PAF). <br> Methods:A total of 60 patients with hypertension combining PAF converted to sinus rhythm were studied and the patients were divided into 2 groups. Control group, the patients received felodipine and Valsartan group. n=30 in each group, all patients were treated for 6 months. In addition, there was a Normal group including 30 healthy subjects. The levels of high sensitive C-reactive protein (hs-CRP), interleukin-6 (IL-6) and left atrial diastolic diameter (LADd), the sinus rhythm maintenance rate were examined and compared before and after treatment among different groups. <br> Results: Compared with Normal group, the levels of hs-CRP, IL-6 and LADd were obviously higher in patients at both Control group and Valsartan group, all P<0.01. With 6 months of treatment, the levels of hs-CRP, IL-6 and LADd were decreased in both groups of patients than they were before, all P<0.01;compared with Control group, such effects were more obvious in Valsartan group, all P<0.01. The sinus rhythm maintenance rate in Valsartan group was signiifcantly higher than that in Control group, P<0.05. <br> Conclusion: Valsartan may inhibit inflammatory response and improve atrial structure remodeling, therefore better maintain the converted sinus rhythm in patients with hypertension combining PAF. The anti-inlfammatory effect of valsartan might be independent from its anti-hypertension effect.
