中国癌症杂志
中國癌癥雜誌
중국암증잡지
CHINA ONCOLOGY
2014年
11期
814-819
,共6页
放射性脑损伤%情绪%记忆
放射性腦損傷%情緒%記憶
방사성뇌손상%정서%기억
Brain irradiation injury%Mood%Memory
背景与目的：放射治疗是脑肿瘤的主要治疗方法之一，但会导致一定的神经毒性。为避免临床混杂因素的干扰，本研究采用大鼠放射性脑损伤模型探讨脑部照射对情绪和记忆的影响及其规律。方法：6~8周SD大鼠，用直线加速器进行脑部照射22 Gy制作放射性脑损伤模型。分别在脑部照射1、10个月后，用旷场实验和高架十字迷宫评价大鼠的活动度及焦虑情绪；用被动回避实验检测大鼠的情绪记忆；用新位置识别检测大鼠的空间记忆。结果：脑部照射1个月后，大鼠在旷场中的移动距离和进入中央区域的次数减少，在高架十字迷宫中的总探索次数和探索开放臂的探索比例降低，在被动回避实验中进入暗室的潜伏时间变短，在新位置识别实验中探索新位置的探索比例降低。脑部照射10个月后，大鼠在旷场和高架十字迷宫中的表现与对照组相比差异均无统计学意义(P>0.05)，但在被动回避实验中进入暗室的潜伏时间，及在新位置识别实验中探索新位置的比例较对照组均降低。结论：脑部照射可导致大鼠活动度降低、恐惧记忆，并可导致空间记忆受损；脑部照射导致的情绪障碍可以恢复，但记忆损伤将长期存在。
揹景與目的：放射治療是腦腫瘤的主要治療方法之一，但會導緻一定的神經毒性。為避免臨床混雜因素的榦擾，本研究採用大鼠放射性腦損傷模型探討腦部照射對情緒和記憶的影響及其規律。方法：6~8週SD大鼠，用直線加速器進行腦部照射22 Gy製作放射性腦損傷模型。分彆在腦部照射1、10箇月後，用曠場實驗和高架十字迷宮評價大鼠的活動度及焦慮情緒；用被動迴避實驗檢測大鼠的情緒記憶；用新位置識彆檢測大鼠的空間記憶。結果：腦部照射1箇月後，大鼠在曠場中的移動距離和進入中央區域的次數減少，在高架十字迷宮中的總探索次數和探索開放臂的探索比例降低，在被動迴避實驗中進入暗室的潛伏時間變短，在新位置識彆實驗中探索新位置的探索比例降低。腦部照射10箇月後，大鼠在曠場和高架十字迷宮中的錶現與對照組相比差異均無統計學意義(P>0.05)，但在被動迴避實驗中進入暗室的潛伏時間，及在新位置識彆實驗中探索新位置的比例較對照組均降低。結論：腦部照射可導緻大鼠活動度降低、恐懼記憶，併可導緻空間記憶受損；腦部照射導緻的情緒障礙可以恢複，但記憶損傷將長期存在。
배경여목적：방사치료시뇌종류적주요치료방법지일，단회도치일정적신경독성。위피면림상혼잡인소적간우，본연구채용대서방사성뇌손상모형탐토뇌부조사대정서화기억적영향급기규률。방법：6~8주SD대서，용직선가속기진행뇌부조사22 Gy제작방사성뇌손상모형。분별재뇌부조사1、10개월후，용광장실험화고가십자미궁평개대서적활동도급초필정서；용피동회피실험검측대서적정서기억；용신위치식별검측대서적공간기억。결과：뇌부조사1개월후，대서재광장중적이동거리화진입중앙구역적차수감소，재고가십자미궁중적총탐색차수화탐색개방비적탐색비례강저，재피동회피실험중진입암실적잠복시간변단，재신위치식별실험중탐색신위치적탐색비례강저。뇌부조사10개월후，대서재광장화고가십자미궁중적표현여대조조상비차이균무통계학의의(P>0.05)，단재피동회피실험중진입암실적잠복시간，급재신위치식별실험중탐색신위치적비례교대조조균강저。결론：뇌부조사가도치대서활동도강저、공구기억，병가도치공간기억수손；뇌부조사도치적정서장애가이회복，단기억손상장장기존재。
Background and purpose:Radiotherapy is one of the main treatment methods for brain tumor patients, but neurotoxicity was observed frequently. Because of the confounding factors in clinical data, it’s hard to summarize the characteristic of neurological changes after brain irradiation. This study used the brain irradiation injury model of rats to test whether brain irradiation change the mood and memory.Methods:Whole brain of SD rats (6-8 weeks old) was exposed to 22 Gy radiation. Open ifeld and elevated plus maze was used to assess the anxiety of rats, passive avoidance was used to assess the mood memory, and novel place recognition was used to assess the spatial memory at 1 month or 10 months after brain irradiation.Results:At 1 month post irradiation, rats moved with less distance and entrance to the central zone of open ifeld with less time, explored the open and closed arms with less time and the exploration of open arms also decreased, entered the darkroom more rapidly during the test phase of passive avoidance, and lose the interest to explore the novel place during novel place recognition. At 10 months post irradiation, rats exhibited similarly with control group during open ifeld and elevated plus maze test, but still entered the darkroom more rapidly during the test phase of passive avoidance, and lose the interest to explore the novel place during novel place recognition.Conclusion:Brain irradiation could decrease the locomotor activity, increase the anxiety mood, reduce the mood and spatial memory; mood dysfunction induced by brain irradiation could restore, but memory impairments would be long-standing.
