实用心脑肺血管病杂志
實用心腦肺血管病雜誌
실용심뇌폐혈관병잡지
PRACTICAL JOURNAL OF CARDIAC CEREBRAL PNEUMAL AND VASCULAR DISEASE
2014年
11期
17-19
,共3页
陶中海%张清秀%吕尤%翟羽佳
陶中海%張清秀%呂尤%翟羽佳
도중해%장청수%려우%적우가
脑梗死%认知障碍%血管性认知功能障碍%危险因素%蒙特利尔量表
腦梗死%認知障礙%血管性認知功能障礙%危險因素%矇特利爾量錶
뇌경사%인지장애%혈관성인지공능장애%위험인소%몽특리이량표
Brain infarction%Cognition disorders%Vascular cognitive impairment%Risk factors%MoCA
目的:探讨脑梗死后血管性认知功能障碍( VCI)的危险因素。方法选择2011年我院收治的78例经中文版蒙特利尔量表( MoCA)评定存在VCI的脑梗死患者作为VCI组,67例同期住院的不存在VCI的脑梗死患者作为对照组,比较两组患者的VCI相关影响因素,包括高龄(≥70岁)和低教育(≤6年)所占比例及高血压、糖尿病、冠心病、高同型半胱氨酸血症、高低密度脂蛋白血症、血管狭窄(>50%)、左侧梗死、多次梗死、大面积梗死、脑白质疏松、吸烟、酗酒、脑萎缩发生率,并将脑梗死后VCI的相关影响因素进行多因素Logistic回归分析;比较两组患者MoCA各项评分及总分。结果单因素分析结果显示, VCI组患者高龄(≥70岁)、低教育(≤6年)所占比例及高血压、糖尿病、血管狭窄(>50%)、左侧梗死、多次梗死、大面积梗死、脑白质疏松、酗酒、脑萎缩发生率均高于对照组(P<0.05)。多因素Logistic回归分析结果显示,高龄(≥70岁)〔OR=5.971,95%CI (0.750,0.902)〕、左侧梗死〔OR=4.861,95%CI (1.244,9.779)〕、糖尿病〔OR=3.563,95%CI (1.181,9.336)〕、血管狭窄(>50%)〔OR=3.013,95%CI (1.272,13.481)〕、大面积梗死〔OR=10.063,95%CI (1.416,33.295)〕、脑白质疏松〔OR=3.361,95%CI (1.580,16.339)〕、脑萎缩〔OR=2.794,95%CI (1.518,16.593)〕、酗酒〔OR=2.421,95%CI (2.403,55.444)〕及多次梗死〔OR=4.538,95%CI (1.165,13.550)〕是脑梗死后VCI的危险因素( P<0.05)。两组患者语言流.能力、命名能力、抽象概括能力及定向能力评分比较,差异无统计学意义( P>0.05); VCI组患者记忆能力、视空间执行能力、注意及计算能力评分及MoCA总分均低于对照组( P<0.05)。结论高龄(≥70岁)、左侧梗死、糖尿病、血管狭窄(>50%)、大面积梗死、脑白质疏松、脑萎缩、酗酒、多次梗死为脑梗死后VCI的危险因素,且VCI早期以记忆能力、视空间执行功能力、注意及计算能力下降为主。
目的:探討腦梗死後血管性認知功能障礙( VCI)的危險因素。方法選擇2011年我院收治的78例經中文版矇特利爾量錶( MoCA)評定存在VCI的腦梗死患者作為VCI組,67例同期住院的不存在VCI的腦梗死患者作為對照組,比較兩組患者的VCI相關影響因素,包括高齡(≥70歲)和低教育(≤6年)所佔比例及高血壓、糖尿病、冠心病、高同型半胱氨痠血癥、高低密度脂蛋白血癥、血管狹窄(>50%)、左側梗死、多次梗死、大麵積梗死、腦白質疏鬆、吸煙、酗酒、腦萎縮髮生率,併將腦梗死後VCI的相關影響因素進行多因素Logistic迴歸分析;比較兩組患者MoCA各項評分及總分。結果單因素分析結果顯示, VCI組患者高齡(≥70歲)、低教育(≤6年)所佔比例及高血壓、糖尿病、血管狹窄(>50%)、左側梗死、多次梗死、大麵積梗死、腦白質疏鬆、酗酒、腦萎縮髮生率均高于對照組(P<0.05)。多因素Logistic迴歸分析結果顯示,高齡(≥70歲)〔OR=5.971,95%CI (0.750,0.902)〕、左側梗死〔OR=4.861,95%CI (1.244,9.779)〕、糖尿病〔OR=3.563,95%CI (1.181,9.336)〕、血管狹窄(>50%)〔OR=3.013,95%CI (1.272,13.481)〕、大麵積梗死〔OR=10.063,95%CI (1.416,33.295)〕、腦白質疏鬆〔OR=3.361,95%CI (1.580,16.339)〕、腦萎縮〔OR=2.794,95%CI (1.518,16.593)〕、酗酒〔OR=2.421,95%CI (2.403,55.444)〕及多次梗死〔OR=4.538,95%CI (1.165,13.550)〕是腦梗死後VCI的危險因素( P<0.05)。兩組患者語言流.能力、命名能力、抽象概括能力及定嚮能力評分比較,差異無統計學意義( P>0.05); VCI組患者記憶能力、視空間執行能力、註意及計算能力評分及MoCA總分均低于對照組( P<0.05)。結論高齡(≥70歲)、左側梗死、糖尿病、血管狹窄(>50%)、大麵積梗死、腦白質疏鬆、腦萎縮、酗酒、多次梗死為腦梗死後VCI的危險因素,且VCI早期以記憶能力、視空間執行功能力、註意及計算能力下降為主。
목적:탐토뇌경사후혈관성인지공능장애( VCI)적위험인소。방법선택2011년아원수치적78례경중문판몽특리이량표( MoCA)평정존재VCI적뇌경사환자작위VCI조,67례동기주원적불존재VCI적뇌경사환자작위대조조,비교량조환자적VCI상관영향인소,포괄고령(≥70세)화저교육(≤6년)소점비례급고혈압、당뇨병、관심병、고동형반광안산혈증、고저밀도지단백혈증、혈관협착(>50%)、좌측경사、다차경사、대면적경사、뇌백질소송、흡연、후주、뇌위축발생솔,병장뇌경사후VCI적상관영향인소진행다인소Logistic회귀분석;비교량조환자MoCA각항평분급총분。결과단인소분석결과현시, VCI조환자고령(≥70세)、저교육(≤6년)소점비례급고혈압、당뇨병、혈관협착(>50%)、좌측경사、다차경사、대면적경사、뇌백질소송、후주、뇌위축발생솔균고우대조조(P<0.05)。다인소Logistic회귀분석결과현시,고령(≥70세)〔OR=5.971,95%CI (0.750,0.902)〕、좌측경사〔OR=4.861,95%CI (1.244,9.779)〕、당뇨병〔OR=3.563,95%CI (1.181,9.336)〕、혈관협착(>50%)〔OR=3.013,95%CI (1.272,13.481)〕、대면적경사〔OR=10.063,95%CI (1.416,33.295)〕、뇌백질소송〔OR=3.361,95%CI (1.580,16.339)〕、뇌위축〔OR=2.794,95%CI (1.518,16.593)〕、후주〔OR=2.421,95%CI (2.403,55.444)〕급다차경사〔OR=4.538,95%CI (1.165,13.550)〕시뇌경사후VCI적위험인소( P<0.05)。량조환자어언류.능력、명명능력、추상개괄능력급정향능력평분비교,차이무통계학의의( P>0.05); VCI조환자기억능력、시공간집행능력、주의급계산능력평분급MoCA총분균저우대조조( P<0.05)。결론고령(≥70세)、좌측경사、당뇨병、혈관협착(>50%)、대면적경사、뇌백질소송、뇌위축、후주、다차경사위뇌경사후VCI적위험인소,차VCI조기이기억능력、시공간집행공능력、주의급계산능력하강위주。
Objective To investigate the risk factors of vascular cognitive impairment ( VCI) after cerebral infarction . Methods In 2011, 78 VCI patients after cerebral infarction diagnosed by MoCA ( Chinese version ) were selected as VCI group in our hospital , 67 cerebral infarction patients without VCI were selected as control group.The related influencing factors of VCI between the two groups were compared , including proportion of elderly ( >70 years) , low education level ( <6 years) and incidences of hypertension, diabetes, coronary disease, hyperhomocysteinemia, hyper-LDL-choleste rolemia, vascular ste-nosis (>50%), left infarction, multiple infarctions, large area infarction, leukoaraiosis, smoking, drinking and brain atro-phy, and then the related influencing factors were analyzed by multivariate Logistic regression analysis.MoCA scores between the two groups were compared too .Results Univariate analysis showed that , the proportion of elderly (>70 years) , low educa-tion level (<6 years) and the incidences of hypertension , diabetes, vascular stenosis (>50%), left infarction, multiple in-farctions, large area infarction, leukoaraiosis, drinking and brain atrophy of VCI group were higher than those of control group (P<0.05) .Multivariate Logistic regression analysis showed that , elderly ( >70 years) 〔OR=5.971, 95%CI (0.750, 0.902)〕, left infarction 〔OR=4.861, 95%CI (1.244, 9.779)〕, diabetes 〔OR=3.563, 95%CI (1.181, 9.336)〕, vascular stenosis ( >50%) 〔OR =3.013, 95%CI (1.272, 13.481)〕, large area infarction 〔OR =10.063, 95%CI (1.416, 33.295)〕, leukoaraiosis 〔OR =3.361, 95%CI ( 1.580, 16.339 )〕, brain atrophy 〔OR =2.794, 95%CI (1.518, 16.593)〕, drinking 〔OR=2.421, 95%CI (2.403, 55.444)〕 and multiple infarctions 〔OR=4.538, 95%CI (1.165, 13.550 )〕 were the risk factors of VCI after cerebral infarction (P<0.05) .There was no significant differences of scores of language fluency , naming ability , abstract generalization ability and orientation ability between the two groups ( P>0.05), while scores of memory, visual spatial execution ability , attention and calculation ability and total score of MoCA of VCI group were lower than those of control group (P<0.05).Conclusion Elderly (>70 years), left infarction, diabetes, vas-cular stenosis (>50%) , large area infarction , leukoaraiosis , brain atrophy , drinking and multiple infarctions are risk factors of VCI after cerebral infarction , and its main performance at the early stage includes decline of memory , visual spatial execution ability, attention and calculation ability .