实用心脑肺血管病杂志
實用心腦肺血管病雜誌
실용심뇌폐혈관병잡지
PRACTICAL JOURNAL OF CARDIAC CEREBRAL PNEUMAL AND VASCULAR DISEASE
2014年
11期
9-11
,共3页
冠心病%内皮素-1%利钠肽,C型%胱抑素C%妊娠相关血浆蛋白A
冠心病%內皮素-1%利鈉肽,C型%胱抑素C%妊娠相關血漿蛋白A
관심병%내피소-1%리납태,C형%광억소C%임신상관혈장단백A
Coronary disease%Endothelin-1%Natriuretic peptide,C-type%Cystatin C%Pregnancy-associated plasma protein-A
目的:探讨冠心病患者血浆内皮素-1( ET-1)和血清C型利钠肽( CNP)、胱抑素C、妊娠相关血浆蛋白A ( PAPPA)水平变化及其临床意义。方法选择我院心内科2012年6月—2013年6月收治的冠心病患者91例为冠心病组,其中稳定型心绞痛( SAP)患者35例( SAP组)、不稳定型心绞痛( UAP)患者33例( UAP组)、急性心肌梗死( AMI)患者23例( AMI组);选择同期在我院体检健康者35例为对照组。检测所有受试者血浆ET-1和血清CNP、胱抑素C、 PAPPA水平,并进行比较。结果冠心病组患者血浆ET-1和血清CNP、胱抑素C、 PAPPA水平均高于对照组( P<0.05)。 SAP组、 UAP组、 AMI组血浆ET-1和血清CNP、胱抑素C、 PAPPA水平均高于对照组, UAP组、 AMI组均高于SAP组, AMI组高于UAP组(P<0.05)。直线回归分析结果显示,冠心病患者血清PAP-PA水平与血浆ET-1(r=0.592)和血清CNP (r=0.602)、胱抑素C (r=0.593)水平均呈正相关(P<0.01)。结论冠心病患者血浆ET-1和血清CNP、胱抑素C、 PAPPA水平明显升高,且随着冠心病严重程度加重而升高。
目的:探討冠心病患者血漿內皮素-1( ET-1)和血清C型利鈉肽( CNP)、胱抑素C、妊娠相關血漿蛋白A ( PAPPA)水平變化及其臨床意義。方法選擇我院心內科2012年6月—2013年6月收治的冠心病患者91例為冠心病組,其中穩定型心絞痛( SAP)患者35例( SAP組)、不穩定型心絞痛( UAP)患者33例( UAP組)、急性心肌梗死( AMI)患者23例( AMI組);選擇同期在我院體檢健康者35例為對照組。檢測所有受試者血漿ET-1和血清CNP、胱抑素C、 PAPPA水平,併進行比較。結果冠心病組患者血漿ET-1和血清CNP、胱抑素C、 PAPPA水平均高于對照組( P<0.05)。 SAP組、 UAP組、 AMI組血漿ET-1和血清CNP、胱抑素C、 PAPPA水平均高于對照組, UAP組、 AMI組均高于SAP組, AMI組高于UAP組(P<0.05)。直線迴歸分析結果顯示,冠心病患者血清PAP-PA水平與血漿ET-1(r=0.592)和血清CNP (r=0.602)、胱抑素C (r=0.593)水平均呈正相關(P<0.01)。結論冠心病患者血漿ET-1和血清CNP、胱抑素C、 PAPPA水平明顯升高,且隨著冠心病嚴重程度加重而升高。
목적:탐토관심병환자혈장내피소-1( ET-1)화혈청C형리납태( CNP)、광억소C、임신상관혈장단백A ( PAPPA)수평변화급기림상의의。방법선택아원심내과2012년6월—2013년6월수치적관심병환자91례위관심병조,기중은정형심교통( SAP)환자35례( SAP조)、불은정형심교통( UAP)환자33례( UAP조)、급성심기경사( AMI)환자23례( AMI조);선택동기재아원체검건강자35례위대조조。검측소유수시자혈장ET-1화혈청CNP、광억소C、 PAPPA수평,병진행비교。결과관심병조환자혈장ET-1화혈청CNP、광억소C、 PAPPA수평균고우대조조( P<0.05)。 SAP조、 UAP조、 AMI조혈장ET-1화혈청CNP、광억소C、 PAPPA수평균고우대조조, UAP조、 AMI조균고우SAP조, AMI조고우UAP조(P<0.05)。직선회귀분석결과현시,관심병환자혈청PAP-PA수평여혈장ET-1(r=0.592)화혈청CNP (r=0.602)、광억소C (r=0.593)수평균정정상관(P<0.01)。결론관심병환자혈장ET-1화혈청CNP、광억소C、 PAPPA수평명현승고,차수착관심병엄중정도가중이승고。
Objective To investigate the changes and clinical significance of plasma ET -1 level, serum CNP, Cys-tatin C and PAPPA levels in patients with coronary heart disease (CHD).Methods From June 2012 to June 2013, 91 patients with CHD were selected as CHD group in our hospital , thereinto 35 patients with SAP were served as SAP group , 33 patients with UAP as UAP group, 23 patients with AMI as AMI group; at the same time, 35 healthy cases were selected as control group.Plasma ET-1 level, serum CNP, Cystatin C and PAPPA levels were detected and compared .Results Plasma ET-1 level, serum CNP, Cystatin C and PAPPA levels of CHD group were higher than those of control group (P<0.05), and those of SAP group, UAP group, AMI group were higher than those of control group , those of UAP group, AMI group were higher than those of SAP group , those of AMI group were higher than those of UAP group ( P<0.05 ) .Linear regression analysis showed that, serum PAPPA level was positively correlated with serum plasma ET -1 level (r=0.592), serum CNP level (r=0.602) and serum Cystatin C level (r=0.593) in patients with CHD, the differences were statistically significantly different (P<0.05).Conclusion Plasma ET-1 level, serum CNP, Cystatin C and PAPPA levels are higher in patients with CHD , and elevates with severity of CHD .