CAJ | 학술논문

促红细胞生成素（erythropoietin，EPO）不仅具有促红细胞生成作用，更是一种多组织分布、具有组织保护作用的多功能细胞因子。近年来，越来越多科学家注意到 EPO 的抗抑郁潜能，并提出可作为新型抗抑郁的选择性药物。该文概括了 EPO 在抗抑郁效应的基础及实验研究，并阐述了其可能机制及其临床应用前景，旨在对 EPO 在抑郁症中的研究及应用现状有一个系统认识。
촉홍세포생성소（erythropoietin，EPO）불부구유촉홍세포생성작용，경시일충다조직분포、구유조직보호작용적다공능세포인자。근년래，월래월다과학가주의도 EPO 적항억욱잠능，병제출가작위신형항억욱적선택성약물。해문개괄료 EPO 재항억욱효응적기출급실험연구，병천술료기가능궤제급기림상응용전경，지재대 EPO 재억욱증중적연구급응용현상유일개계통인식。
Erythropoietin (EPO),which is routinely used in clinic to treat anemia,has been implicated in a wide range of activities on diverse tissues.Recently,accumulating evidence shows that EPO has antidepressant-like effects and may be a po-tential drug candidate for treating mood symptoms and memory dysfunction in depression.This review summarizes the current progress on EPO’s antidepressant-like effects,and explores its potential mechanism and clinical application in the future,provi-ding a general view of the research and application status of EPO in depression.