CAJ | 학술논문

目的：探讨电针内关、心俞、关元俞对急性心肌缺血兔心功能的影响。方法36只兔按随机数字表法分为对照组、模型组和治疗组，每组12只。经颈静脉注射垂体后叶素制作兔急性心肌缺血模型，分别于造模前10 min、造模后1 h及治疗后1周检测心肌组织丙二醛（MDA）、血清肌酸激酶（CK）浓度，并通过检测各组左心室内压最大上升速率（dp/dtmax）和左心室内压力峰值（LVSP）评价心功能。结果电针治疗1周后，治疗组CK、MDA浓度降低[分别为（120.21±10.67）IU/L、（21.35±2.04）mmol/L]，与模型组[分别为（162.37±13.21）U/L、（30.13±2.75）mmol/L]比较差异有统计学意义（P 均＜0.05）；dp/dtmax和 LVSP 下降率[分别为（20.0±2.43）%、（7.22±0.97）%]较模型组[分别为（31.5±4.14）%、（12.19±2.21）%]降低（P均＜0.05）。结论电针内关、心俞、关元俞配穴可改善兔急性心肌缺血后心功能，对兔急性心肌缺血有保护作用。
목적：탐토전침내관、심유、관원유대급성심기결혈토심공능적영향。방법36지토안수궤수자표법분위대조조、모형조화치료조，매조12지。경경정맥주사수체후협소제작토급성심기결혈모형，분별우조모전10 min、조모후1 h급치료후1주검측심기조직병이철（MDA）、혈청기산격매（CK）농도，병통과검측각조좌심실내압최대상승속솔（dp/dtmax）화좌심실내압력봉치（LVSP）평개심공능。결과전침치료1주후，치료조CK、MDA농도강저[분별위（120.21±10.67）IU/L、（21.35±2.04）mmol/L]，여모형조[분별위（162.37±13.21）U/L、（30.13±2.75）mmol/L]비교차이유통계학의의（P 균＜0.05）；dp/dtmax화 LVSP 하강솔[분별위（20.0±2.43）%、（7.22±0.97）%]교모형조[분별위（31.5±4.14）%、（12.19±2.21）%]강저（P균＜0.05）。결론전침내관、심유、관원유배혈가개선토급성심기결혈후심공능，대토급성심기결혈유보호작용。
Objective To investigate the effect of electro-acupuncture at Guanyuanshu, Xinshu, Neiguan points on cardiac function after acute myocardial ischemia in rabbits. Methods A total of 36 rabbits were randomly divided into a control group, a model group and a treatment group. Acute myocardial ischemia was induced with Jugular vein injection of pituitrin. At 10 min before modeling, 1 hour and 1 week after modeling, the levels of malondialdehyde (MDA) and creatine kinase(CK) were determined respectively, the cardiac function was assessed as the maximum rate of left ventricular pressure rise(dp/dtmax)and the peak left ventricular pressure (LVSP). Results After 1 week of treatment, the serum levels of CK and MDA in the treatment group reduced significantly(120.21±10.67 U/L, 21.35±2.04 mmol/L], compared to the model group (162.37±13.21 U/L, 30.13±2.75 mmol/L) (all P<0.05);the dp/dtmax and LVSP decreased percentage in the treatment group (20%±2.43%, 7.22%±0.97%) decrease significantly compared to the model group (31.5%± 4.14%, 12.19%±2.21%) (all P<0.05). Conclusion Electro-acupuncture of Guanyuanshu, Xinshu, Neiguan acupoints can significantly improve cardiac function after acute myocardial ischemia and protect against acute myocardial ischemia in rabbits.