CAJ | 학술논문

目的：评价中西医结合治疗中风后癫痫的疗效。方法检索中国期刊全文数据库（CNKI）、中文科技期刊数据库（VIP）、中国学术期刊数据库（万方数据）、PubMed数据库中有关中西医结合治疗中风后癫痫的临床研究文献，筛选出中西医结合与西药对比治疗中风后癫痫的随机对照试验，采用RevMan 5软件进行统计分析。结果有7篇文献纳入研究，各研究间存在同质性（P＞0.05），采用固定效应模型进行meta分析，合并后OR＝5.17，95%CI（3.02，8.82），整体效应检验Z＝6.01，P＜0.01，治疗组与对照组疗效比较，差异有统计学意义，可认为中西医结合治疗中风后癫痫的总体效果优于对照组；倒漏斗图的图形显示不对称，表明文献存在发表偏倚。结论中西医结合治疗中风后癫痫的疗效优于单纯西药治疗，但由于文献存在发表偏倚，需要更多高质量大样本的临床研究进行证明。
목적：평개중서의결합치료중풍후전간적료효。방법검색중국기간전문수거고（CNKI）、중문과기기간수거고（VIP）、중국학술기간수거고（만방수거）、PubMed수거고중유관중서의결합치료중풍후전간적림상연구문헌，사선출중서의결합여서약대비치료중풍후전간적수궤대조시험，채용RevMan 5연건진행통계분석。결과유7편문헌납입연구，각연구간존재동질성（P＞0.05），채용고정효응모형진행meta분석，합병후OR＝5.17，95%CI（3.02，8.82），정체효응검험Z＝6.01，P＜0.01，치료조여대조조료효비교，차이유통계학의의，가인위중서의결합치료중풍후전간적총체효과우우대조조；도루두도적도형현시불대칭，표명문헌존재발표편의。결론중서의결합치료중풍후전간적료효우우단순서약치료，단유우문헌존재발표편의，수요경다고질량대양본적림상연구진행증명。
Objective To evaluate clinical effects of integrated traditional Chinese and western medicine therapy for epilepsy after stroke. Methods Literatures about the treatment of epilepsy after stroke with the combination of traditional Chinese medicine and western medicine which come from the database such as CNKI, VIP, WanFang and Pubmed, were studied and all the randomized controlled trials on comparing therapeutic effects of treating epilepsy between combined treatment of TCM and western medicine and western medicine were enrolled. The Cochrane Collaboration's software RevMan 5 was used for meta-analysis. Results 7 articles were included in the study, there is homogeneity among these articles(P>0.05), The fixed effect model was used for the meta analysis. the combined results were OR=5.17, 95%CI(3.02, 8.82), the overall effect of test Z=6.01, P<0.01, the difference between the treatment group and the control groups was significant, that means the overall effect of the combination of traditional Chinese medicine and Western medicine treatment was better than western medicine treatment; Funnel plot graphic displayed asymmetrically, which indicated the literatures publication bias. Conclusion The current data indicate that the curative effect of TCM and west medicine combined treatment is better than pure western medicine therapy for epilepsy after stroke, but as the literature publication bias, clinical studies need more high quality large samples to prove this conclusion.