CAJ | 학술논문

目的：观察川芎平喘合剂治疗慢性持续期支气管哮喘患者的临床疗效。方法：将148例患者随机分为对照组和治疗组各74例，对照组采用舒利迭治疗，治疗组采用川芎平喘合剂治疗。观察2组治疗前后白介素（IL）-4、IL-6、IL-8、IL-10的变化情况。结果：对照组显效率48.44%，总有效率62.16%；治疗组显效率71.62%，总有效率86.49%；显效率、总有效率2组比较，差异有统计学意义（P＜0.05）。 IL-6、IL-8、治疗3个月后和6个月后2组比较差异有统计学意义（P＜0.05）；IL-4、IL-6、IL-8治疗9个月后2组比较差异有统计学意义（P＜0.05）；IL-4、IL-6、IL-8、IL-10治疗1年后2组比较差异有统计学意义（P＜0.05）。结论：川芎平喘合剂治疗慢性持续期支气管哮喘临床疗效显著，且可降低IL-4、IL-6、IL-8水平。
목적：관찰천궁평천합제치료만성지속기지기관효천환자적림상료효。방법：장148례환자수궤분위대조조화치료조각74례，대조조채용서리질치료，치료조채용천궁평천합제치료。관찰2조치료전후백개소（IL）-4、IL-6、IL-8、IL-10적변화정황。결과：대조조현효솔48.44%，총유효솔62.16%；치료조현효솔71.62%，총유효솔86.49%；현효솔、총유효솔2조비교，차이유통계학의의（P＜0.05）。 IL-6、IL-8、치료3개월후화6개월후2조비교차이유통계학의의（P＜0.05）；IL-4、IL-6、IL-8치료9개월후2조비교차이유통계학의의（P＜0.05）；IL-4、IL-6、IL-8、IL-10치료1년후2조비교차이유통계학의의（P＜0.05）。결론：천궁평천합제치료만성지속기지기관효천림상료효현저，차가강저IL-4、IL-6、IL-8수평。
Objective: To explore curative effects of ChuanXiong PingChuan mixture in treating chronic bronchial asthma at persistent stage. Methods:All 148 patients were randomized into the control group and the treat-ment group, the control group were treated by salmeterol and fluticasone propionate inhalation and the treatment group ChuanXiong PingChuan mixture. The changes of Interleukin-4 (IL-4), IL-6, IL-8 and IL-10 of both groups were observed before and after treating. Results:Markedly effective rate of the control group was 48.44%, total ef-fective rate 62.16%;while markedly effective rate and total effective rate of the treatment group were 71.62%and 86.49%;the difference was significant between both groups (P<0.05). The difference was notable in the compari-son of IL-6 and IL-8 in three and six months after treating (P<0.05);The difference was striking in the comparison of IL-4, IL-6 and IL-8 in nine months after treating (P<0.05);also in IL-4, IL-6, IL-8 and IL-10 in one year after treating (P<0.05). Conclusion:ChuanXiong PingChuan mixture is effective in treating chronic bronchial asthma at persistent stage, and it could decrease the levels of IL-4, IL-6 and IL-8.