CAJ | 학술논문

目的：观察疏肝理气中药治疗糖尿病周围神经病变的临床疗效。方法：将64患者随机分为治疗组、对照组各32例，2组患者均给予皮下注射胰岛素控制血糖，治疗组予疏肝理气中药内服，1剂/d，对照组予甲钴胺片500μg，3次/d，口服。2组均以治疗16周为1个疗程。观察2组治疗前后空腹血糖(FBG)、餐后2小时血糖(PBG)、甘油三酯(TG)、高敏C反应蛋白（CRP）、血浆内皮素(ET)及神经传导速度的变化，并计算治疗前后胰岛素抵抗指数（HOMA-IR）。结果：总有效率治疗组为91.0%，对照组为84.0%，2组比较差异有统计学意义（P＜0.05）。 FBG、PBG治疗后2组均明显降低(P＜0.05)，组间比较差异无统计学意义(P＞0.05)。 TG、ET、CRP、HOMA-IR治疗后治疗组明显下降(P＜0.05)，组间比较差异有统计学意义(P＜0.05)。神经传导速度2组治疗前后组内比较差异显著(P＜0.05)，治疗组改善更明显（P＜0.05）。结论：疏肝理气中药治疗糖尿病周围神经病变临床疗效显著，可提高患者神经传导速度。
목적：관찰소간리기중약치료당뇨병주위신경병변적림상료효。방법：장64환자수궤분위치료조、대조조각32례，2조환자균급여피하주사이도소공제혈당，치료조여소간리기중약내복，1제/d，대조조여갑고알편500μg，3차/d，구복。2조균이치료16주위1개료정。관찰2조치료전후공복혈당(FBG)、찬후2소시혈당(PBG)、감유삼지(TG)、고민C반응단백（CRP）、혈장내피소(ET)급신경전도속도적변화，병계산치료전후이도소저항지수（HOMA-IR）。결과：총유효솔치료조위91.0%，대조조위84.0%，2조비교차이유통계학의의（P＜0.05）。 FBG、PBG치료후2조균명현강저(P＜0.05)，조간비교차이무통계학의의(P＞0.05)。 TG、ET、CRP、HOMA-IR치료후치료조명현하강(P＜0.05)，조간비교차이유통계학의의(P＜0.05)。신경전도속도2조치료전후조내비교차이현저(P＜0.05)，치료조개선경명현（P＜0.05）。결론：소간리기중약치료당뇨병주위신경병변림상료효현저，가제고환자신경전도속도。
Objective:To observe curative effects of liver-soothing Qi-regulating method in treating diabetic peripheral neuropathy (DPN). Methods:Sixty-four patients were randomized into the treatment group and the control group, they accepted subcutaneous injection of insulin to control blood glucose to fasting blood glucose (FBG), the treatment group took the herbs of liver-soothing Qi-regulating, one dose each day, the control group were administered with mecobalamine tablets, 500μg, three times per day, orally. One course of the treatment was 16 weeks. The changes of FBG before and after treating, 2h postprandial blood glucose, glycerin trimyristate (TG), high sensitivity C reactive protein (CRP), endothelin (ET) and nerve conduction velocity (NCV) were observed, homestasis model of assessment for insulin resistance index (HOMA-IR) before and after treating was calculated. Results:Total effective rates of both groups were 91.0%and 84.0%, the difference between both groups was notable (P<0.05). FBG, PBG of both groups were decreased after treating (P<0.05), there was no difference between both groups (P>0.05). TG, ET, CRP, HOMA-IR of the treatment group were lowered obviously after treating (P<0.05), the difference was notable between both groups (P<0.05). The difference was significant in NCV between before and after treating (P<0.05), the improvement of the treatment group was more notable (P<0.05). Conclusion:Herbs of liv-er-soothing Qi-regulating could obtain better effects in treating DPN, and it could improve NCV of the patients.