CAJ | 학술논문

目的：探究吉西他滨和替吉奥联合在晚期胰腺癌治疗中的临床价值，并在临床工作中进行推广使用。方法选取在我院进行治疗的晚期胰腺癌患者34例，分为观察组和对照组两组，每组17例。观察组患者应用吉西他滨联合替吉奥进行治疗，而对照组患者应用吉西他滨单药进行治疗，观察两组患者治疗的有效率以及不良反应发生率，并进行比较。结果观察组患者的总有效率明显高于对照组患者，差异均具有统计学意义（P＜0.05），而不良反应的发生率以及生存时间的差异无统计学意义（P＞0.05）。结论采用吉西他滨与替吉奥联合治疗治疗晚期胰腺癌，在不增加不良反应的基础上，可以提高治疗的有效率，具有重要的临床应用价值。
목적：탐구길서타빈화체길오연합재만기이선암치료중적림상개치，병재림상공작중진행추엄사용。방법선취재아원진행치료적만기이선암환자34례，분위관찰조화대조조량조，매조17례。관찰조환자응용길서타빈연합체길오진행치료，이대조조환자응용길서타빈단약진행치료，관찰량조환자치료적유효솔이급불량반응발생솔，병진행비교。결과관찰조환자적총유효솔명현고우대조조환자，차이균구유통계학의의（P＜0.05），이불량반응적발생솔이급생존시간적차이무통계학의의（P＞0.05）。결론채용길서타빈여체길오연합치료치료만기이선암，재불증가불량반응적기출상，가이제고치료적유효솔，구유중요적림상응용개치。
Objective To explore the clinical value of gemcitabine combined with S-1 in patients with pancreatic cancer, and it should be widely used in clinical work.Methods Selected 34 cases of patients with pancreatic cancer, and we divided them into the control group and the observation group, 17 cases in each group. The patients in observation group received gemcitabine combined with S-1 for treatment, while the control group were treated with gemcitabine, and we recorded the efifciency and adverse reaction rate, then we compared.Results The total effective rate of the observation group was signiifcantly higher than that of the control group, and the differences were statistically signiifcant (P<0.05). And compared the adverse reaction rate of the two groups, there was no statistically signiifcance (P>0.05).Conclusion For patients with pancreatic cancer, gemcitabine combined with S-1 for treatment can improve the treatment efifciency, which has important value in clinical application.