CAJ | 학술논문

目的：分析男性良性黑棘皮病患者瘦素、脂联素及性激素的水平。方法分别采用酶联免疫吸附试验和放射免疫分析法对2010年1月至2013年12月经中国医科大学附属第一医院及沈阳医学院附属中心医院确诊的15例男性良性黑棘皮病患者血清中瘦素、脂联素及性激素（雌二醇、睾酮、促黄体生成素、泌乳素、卵泡刺激素）进行检测，并与20名健康对照进行比较。结果男性良性黑棘皮病患者体质量、体质指数、脂肪百分比明显高于健康对照组[（88±6）比（62±5） kg，（31．7±2．1）比（22．2±2．7）kg／m2，33．3％±2．6％比29．0％±5．8％，均P＜0．05]，血清中瘦素水平明显高于健康对照组[（8．0±1．1）比（4．5±1．5）μg ／L， P＜0．01]，脂联素水平明显低于健康对照组[（27．7±4．8）比（38．6±5．8）μg ／L，P ＜0．01]，性激素中雌二醇及睾酮水平高于健康对照组[（112±28）比（38±7）pmol／L，（7．3±1．9）比（3．9±2．0）nmol／L，均P＜0．01]；黄体生成素水平低于健康对照组[（128±11）vs（155±24）U／L，P＜0．01]。男性良性黑棘皮病患者泌乳素及卵泡刺激素水平与健康对照组相比，差异无统计学意义（均P＞0．05）。结论良性黑棘皮病患者存在瘦素、脂联素与性激素水平的异常，瘦素水平的异常可能与性激素水平变化之间存在某种联系。
목적：분석남성량성흑극피병환자수소、지련소급성격소적수평。방법분별채용매련면역흡부시험화방사면역분석법대2010년1월지2013년12월경중국의과대학부속제일의원급침양의학원부속중심의원학진적15례남성량성흑극피병환자혈청중수소、지련소급성격소（자이순、고동、촉황체생성소、비유소、란포자격소）진행검측，병여20명건강대조진행비교。결과남성량성흑극피병환자체질량、체질지수、지방백분비명현고우건강대조조[（88±6）비（62±5） kg，（31．7±2．1）비（22．2±2．7）kg／m2，33．3％±2．6％비29．0％±5．8％，균P＜0．05]，혈청중수소수평명현고우건강대조조[（8．0±1．1）비（4．5±1．5）μg ／L， P＜0．01]，지련소수평명현저우건강대조조[（27．7±4．8）비（38．6±5．8）μg ／L，P ＜0．01]，성격소중자이순급고동수평고우건강대조조[（112±28）비（38±7）pmol／L，（7．3±1．9）비（3．9±2．0）nmol／L，균P＜0．01]；황체생성소수평저우건강대조조[（128±11）vs（155±24）U／L，P＜0．01]。남성량성흑극피병환자비유소급란포자격소수평여건강대조조상비，차이무통계학의의（균P＞0．05）。결론량성흑극피병환자존재수소、지련소여성격소수평적이상，수소수평적이상가능여성격소수평변화지간존재모충련계。
Objective To explore the serum levels of leptin , adiponectin and sex hormone and their relationship in benign acanthosis nigricans of males .Methods A total of 15 males patients with benign acanthosis nigricans were recruited from January 2010 to December 2013.The serum concentrations of leptin, adiponectin and sex hormone were measured with radioimmunoassay and enzyme-linked immunoabsorbant assay ( ELISA ) respectively.Results As compared with normal control , the values of body mass,body mass index and %Fat were much higher in benign acanthosis nigricans of males ((88 ±6) vs (62 ±5) kg, (31.7 ±2.1) vs (22.2 ±2.7) kg/m2, 33.3%±2.6% vs 29.0%±5.8%, all P<0.05), leptin was much higher ((8.0 ±1.1) vs (4.5 ±1.5) μg/L, P<0.01), adiponectin was much lower ((27.7 ±4.8) vs (38.6 ±5.8) μg/L, P<0.01), estradiol and testosterone were much higher ((112 ±28)vs(38 ±7)pmol/L, (7.3 ±1.9) vs (3.9 ±2.0) nmol/L, both P <0.01), luteinizing hormone was much lower ( ( 128 ±11 ) vs ( 155 ±24 ) U/L, P <0.01 ) . And prolactin and follicle stimulating hormone were not significantly different between two groups ( both P >0.05 ) .Conclusions Benign acanthosis nigricans is associated with abnormal levels of lepin , adiponectin and sex hormone .And there may be some relationship between the abnormal levels of lepin and sex hormone in benign acanthosis nigricans.