中国实用医药
中國實用醫藥
중국실용의약
CHINA PRACTICAL MEDICAL
2014年
36期
40-41
,共2页
李红义%张祥杰%曹臣龙%窦海宾
李紅義%張祥傑%曹臣龍%竇海賓
리홍의%장상걸%조신룡%두해빈
睡眠呼吸暂停%左心功能%脑利钠肽前体氨基末端%心肌工作指数
睡眠呼吸暫停%左心功能%腦利鈉肽前體氨基末耑%心肌工作指數
수면호흡잠정%좌심공능%뇌리납태전체안기말단%심기공작지수
Sleep apnea%Left heart function%Pro-brain natriuretic peptide%Myocardial performance index
目的：探讨阻塞性睡眠呼吸暂停低通气综合征(OSAHS)严重程度与左心功能不全相关性。方法200例经多导睡眠呼吸监测确诊为OSAHS的患者及30例正常受试者作为研究对象,免疫法测血浆脑利钠肽前体氨基末端(NT-proBNP),多普勒超声检测心肌工作指数(MPI)评价心功能。分析正常、轻、中重度OSAHS患者的NT-proBNP及MPI的情况。结果正常、轻度睡眠呼吸暂停、中重度睡眠呼吸暂停患者NT-proBNP分别为(357±184)pg/ml、(579±352)pg/ml、(958±517)pg/ml, MPI分别为(0.26±0.05)、(0.29±0.08)、(0.43±0.17)。中重度睡眠呼吸暂停患者中N-BNP与MPI均明显高于正常及轻度睡眠呼吸暂停患者,且差异具有统计学意义(P<0.05)。结论 OSAHS对左心功能产生不同程度的影响,中重度OSAHS患者心衰程度进一步加重。
目的：探討阻塞性睡眠呼吸暫停低通氣綜閤徵(OSAHS)嚴重程度與左心功能不全相關性。方法200例經多導睡眠呼吸鑑測確診為OSAHS的患者及30例正常受試者作為研究對象,免疫法測血漿腦利鈉肽前體氨基末耑(NT-proBNP),多普勒超聲檢測心肌工作指數(MPI)評價心功能。分析正常、輕、中重度OSAHS患者的NT-proBNP及MPI的情況。結果正常、輕度睡眠呼吸暫停、中重度睡眠呼吸暫停患者NT-proBNP分彆為(357±184)pg/ml、(579±352)pg/ml、(958±517)pg/ml, MPI分彆為(0.26±0.05)、(0.29±0.08)、(0.43±0.17)。中重度睡眠呼吸暫停患者中N-BNP與MPI均明顯高于正常及輕度睡眠呼吸暫停患者,且差異具有統計學意義(P<0.05)。結論 OSAHS對左心功能產生不同程度的影響,中重度OSAHS患者心衰程度進一步加重。
목적：탐토조새성수면호흡잠정저통기종합정(OSAHS)엄중정도여좌심공능불전상관성。방법200례경다도수면호흡감측학진위OSAHS적환자급30례정상수시자작위연구대상,면역법측혈장뇌리납태전체안기말단(NT-proBNP),다보륵초성검측심기공작지수(MPI)평개심공능。분석정상、경、중중도OSAHS환자적NT-proBNP급MPI적정황。결과정상、경도수면호흡잠정、중중도수면호흡잠정환자NT-proBNP분별위(357±184)pg/ml、(579±352)pg/ml、(958±517)pg/ml, MPI분별위(0.26±0.05)、(0.29±0.08)、(0.43±0.17)。중중도수면호흡잠정환자중N-BNP여MPI균명현고우정상급경도수면호흡잠정환자,차차이구유통계학의의(P<0.05)。결론 OSAHS대좌심공능산생불동정도적영향,중중도OSAHS환자심쇠정도진일보가중。
immunization, and myocardial performance index was detected by Doppler ultrasound to evaluate cardiac function. The results of NT-proBNP and MPI were analyzed in normal, mild, and moderately severe OSAHS patients. Results The levels of NT-proBNP in patients with normal, mild, and moderately severe OSAHS were (357±184) pg/ml, (579±352)pg/ml, (958 ± 517) pg/ml, and MPI levels were (0.26±0.05), (0.29±0.08), (0.43±0.17). The levels of NT-proBNP and MPI are obviously higher in patients with moderately severe OSAHS than others with normal and mild degrees, and the difference had statistical significance (P<0.05). Conclusion OSAHS has different influences on left heart function, and moderately severe OSAHS patients has more severe degree of heart failure.
