CAJ | 학술논문

目的：美沙拉嗪(5-ASA)肠溶片剂联合栓剂治疗活动期直乙结肠型溃疡性结肠炎(UC)的疗效。方法80例活动期直乙结肠型溃疡性结肠炎患者，随机分观察组和对照组，各40例。对照组给予美沙拉嗪肠溶片治疗，观察组给予美沙拉嗪肠溶片联合栓剂治疗。观察两组治疗效果和不良反应。结果接受上述治疗2周时，两组治疗总有效率比较差异无统计学意义(P>0.05)。治疗4、6、8周时，两组治疗总有效率比较差异具有统计学意义(P<0.05)。结论口服5-ASA肠溶片与5-ASA栓剂联合使用对我国轻中度UC患者疗效及耐受性良好。
목적：미사랍진(5-ASA)장용편제연합전제치료활동기직을결장형궤양성결장염(UC)적료효。방법80례활동기직을결장형궤양성결장염환자，수궤분관찰조화대조조，각40례。대조조급여미사랍진장용편치료，관찰조급여미사랍진장용편연합전제치료。관찰량조치료효과화불량반응。결과접수상술치료2주시，량조치료총유효솔비교차이무통계학의의(P>0.05)。치료4、6、8주시，량조치료총유효솔비교차이구유통계학의의(P<0.05)。결론구복5-ASA장용편여5-ASA전제연합사용대아국경중도UC환자료효급내수성량호。
Objective To analyze the curative effect of mesalazin (5-ASA) enteric-coated tablets combined with suppository in the treatment of active stage straight b colon ulcerative colitis (UC). Methods A total of 80 patients with active stage straight b colon ulcerative colitis were randomly divided into observation group and control group, with 40 cases in each group. The control group received 5-ASA enteric-coated tablets for treatment, and the observation group was treated by 5-ASA enteric-coated tablets combined with suppository. Curative effects and adverse reactions of the two groups were observed. Results After 2 weeks of treatment, there was no statistically significant difference of the total effective rate between the two groups (P>0.05). In 4, 6, and 8 weeks of treatment, the difference of the total effective rate between the two groups had statistical significance (P<0.05). Conclusion The combination application of oral 5-ASA enteric-coated tablets and 5-ASA suppository can provide good curative effect and tolerance for mild and moderate UC patients in China.