CAJ | 학술논문

目的：探讨多发性骨髓瘤患者(MM)血清乳酸脱氢酶(LDH)和β2微球蛋白(β2-MG)水平测定的临床意义。方法：分别采用速率法和放射免疫法测定35例MM患者和20例健康体检者血清LDH和β2-MG值。结果：分别对不同分期患者血清β2-MG和LDH进行比较，二者表达均为Ⅲ期明显高于Ⅱ期，Ⅱ期明显高于Ⅰ期，Ⅰ期高于对照组，差异有统计学意义(P＜0.05)。化疗前与化疗后(有效组)患者β2-MG与LDH相比，后组明显低于前组，差异有统计学意义(P＜0.05)。结论：β2-MG和LDH水平与MM患者分期相关，可作为判断疗效及预后的相关指标。
목적：탐토다발성골수류환자(MM)혈청유산탈경매(LDH)화β2미구단백(β2-MG)수평측정적림상의의。방법：분별채용속솔법화방사면역법측정35례MM환자화20례건강체검자혈청LDH화β2-MG치。결과：분별대불동분기환자혈청β2-MG화LDH진행비교，이자표체균위Ⅲ기명현고우Ⅱ기，Ⅱ기명현고우Ⅰ기，Ⅰ기고우대조조，차이유통계학의의(P＜0.05)。화료전여화료후(유효조)환자β2-MG여LDH상비，후조명현저우전조，차이유통계학의의(P＜0.05)。결론：β2-MG화LDH수평여MM환자분기상관，가작위판단료효급예후적상관지표。
Objective:To explore the clinical significance of serum lactate dehydrogenase(LDH) andβ2 microglobulin(β2-MG) level measurement in patients with multiple myeloma.Methods:The serum LDH andβ2-MG values of 35 MM patients and 20 healthy controls were measured by using velocity method and radioimmunoassay.Results:The serumβ2-MG and LDH of patients in different stages were respectively compared.The both express were all that phaseⅢwas significantly higher than that of phaseⅡ;phaseⅡwas significantly higher than that of phaseⅠ;phaseⅠwas higher than that of the control group;the difference was statistically significant(P<0.05).Theβ2-MG and LDH of patients were compared before chemotherapy and after chemothera-py(the effective group);the later group was significantly lower than those of the former group;the difference was statistically signifi-cant(P<0.05).Conclusion:Theβ2-MG and LDH level are related to the stages of patients with MM.They can be used as the rela-tive indexes to judge curative effect and prognosis.