CAJ | 학술논문

目的：探讨托烷司琼不同给药时间对乳腺癌改良根治术后恶心呕吐的影响。方法：选择ASAⅠ～Ⅱ级择期行乳腺癌改良根治术女性患者90例，作为研究对象，随机分为A、B和C组，每组30例，采用统一的全身麻醉方案，A组于麻醉诱导前5 min静推托烷司琼5 mg和手术结束前5 min静推0.9%氯化钠注射液5 mL，B组于麻醉诱导前5 min静推0.9%氯化钠注射液5 mL和手术结束前5 min静推托烷司琼5 mg，对照组C组分别于麻醉诱导前5 min和手术结束前5 min各静推0.9%氯化钠注射液5 mL。结果：术后24 h A组和B组术后恶心呕吐发生率分别为6.7%和26.7%，显著低于对照组C组的53.3%(P＜0.001和P=0.035)；且A组术后恶心呕吐发生率显著低于B组(P＜0.05)。结论：托烷司琼可有效用于预防乳腺癌改良根治术后恶心呕吐，且麻醉前给药效果更佳。
목적：탐토탁완사경불동급약시간대유선암개량근치술후악심구토적영향。방법：선택ASAⅠ～Ⅱ급택기행유선암개량근치술녀성환자90례，작위연구대상，수궤분위A、B화C조，매조30례，채용통일적전신마취방안，A조우마취유도전5 min정추탁완사경5 mg화수술결속전5 min정추0.9%록화납주사액5 mL，B조우마취유도전5 min정추0.9%록화납주사액5 mL화수술결속전5 min정추탁완사경5 mg，대조조C조분별우마취유도전5 min화수술결속전5 min각정추0.9%록화납주사액5 mL。결과：술후24 h A조화B조술후악심구토발생솔분별위6.7%화26.7%，현저저우대조조C조적53.3%(P＜0.001화P=0.035)；차A조술후악심구토발생솔현저저우B조(P＜0.05)。결론：탁완사경가유효용우예방유선암개량근치술후악심구토，차마취전급약효과경가。
Objective:To explore the effect of tropisetron at different administration time on breast cancer modified radical postoperative nausea and vomiting.Methods:90 cases of ASAⅠ~Ⅱgrade female patients with elective breast cancer modified radical were selected as the research objects.They were randomly divided into A,B and C group with 30 cases in each.They were adopted a unified general anesthesia scheme.A group were given intravenous injection 5 mg tropisetron 5 minutes before anesthesia induction and intravenous injection 5 mL normal saline 5 minutes before the end of surgery.B group were given intravenous injection 5 mL normal saline 5 minutes before anesthesia induction and intravenous injection 5 mg tropisetron 5 minutes before the end of surgery.The control group(C group) were respectively intravenous injection 5 mL normal saline 5 minutes before anesthesia induction and 5 minutes before the end of surgery.Results:After postoperative 24 hours,the incidence rates of postoperative nausea and vomiting of patients in A group and B group were respectively 6.7%and 26.7%,which were significantly lower than 53.3%of the control group(C group)(P<0.001 and P=0.035).The incidence rate of postoperative nausea and vomiting of A group was significantly lower than that of B group(P<0.038).Conclusion:Tropisetron can be effectively used for the prevention of breast cancer modified radical postoperative nausea and vomiting,and the effect of preanesthetic medication is better.