CAJ | 학술논문

目的：探讨厄贝沙坦氢氯噻嗪片与厄贝沙坦片治疗原发性轻中度高血压疗效差异，指导临床选择疗效佳的药物。方法：2013年2月-2014年9月收治原发性轻中度高血压患者156例，随机分成厄贝沙坦氢氯噻嗪组与厄贝沙坦组各78例，厄贝沙坦氢氯噻嗪组给予厄贝沙坦氢氯噻嗪1片/次，1次/d，厄贝沙坦组给予厄贝沙坦1片/次，1次/d，两组均连续治疗2周。结果：两组经过治疗，收缩压和舒张压均明显下降，与用药前比较差异有统计学意义(P＜0.05)，疗程结束时和疗程结束4周，厄贝沙坦氢氯噻嗪组的收缩压和舒张压均明显低于厄贝沙坦组，两组比较差异有统计学意义(P＜0.05)，两组治疗后尿Alb和血尿酸均明显下降，治疗前后比较差异有统计学意义(P＜0.05)，且厄贝沙坦氢氯噻嗪组明显优于厄贝沙坦组，两组比较差异有统计学意义(P＜0.05)，TC、BUN、TG和CR治疗前后比较差异无统计学意义(P＞0.05)。结论：厄贝沙坦氢氯噻嗪片治疗原发性高血压优于厄贝沙坦片，临床上要首选厄贝沙坦氢氯噻嗪片进行治疗。
목적：탐토액패사탄경록새진편여액패사탄편치료원발성경중도고혈압료효차이，지도림상선택료효가적약물。방법：2013년2월-2014년9월수치원발성경중도고혈압환자156례，수궤분성액패사탄경록새진조여액패사탄조각78례，액패사탄경록새진조급여액패사탄경록새진1편/차，1차/d，액패사탄조급여액패사탄1편/차，1차/d，량조균련속치료2주。결과：량조경과치료，수축압화서장압균명현하강，여용약전비교차이유통계학의의(P＜0.05)，료정결속시화료정결속4주，액패사탄경록새진조적수축압화서장압균명현저우액패사탄조，량조비교차이유통계학의의(P＜0.05)，량조치료후뇨Alb화혈뇨산균명현하강，치료전후비교차이유통계학의의(P＜0.05)，차액패사탄경록새진조명현우우액패사탄조，량조비교차이유통계학의의(P＜0.05)，TC、BUN、TG화CR치료전후비교차이무통계학의의(P＞0.05)。결론：액패사탄경록새진편치료원발성고혈압우우액패사탄편，림상상요수선액패사탄경록새진편진행치료。
Objective:To explore the curative effect of irbesartan hydrochlorothiazide tablets and irbesartan tablets in the treatment of primary mild and moderate hypertension,to guide the clinical drug of choice of good curative effect.Methods:156 patients with primary mild and moderate hypertension were selected from February 2013 to September 2014.They were randomly divided into the irbesartan hydrochlorothiazide group and irbesartan group with 78 cases in each group.Irbesartan hydrochlorothiazide group were given irbesartan hydrochlorothiazide,1 tablet each time,1 time/day.Irbesartan group were given irbesartan,1 tablet each time,1 time/day,two groups were treated continuously for 2 weeks.Results:The two groups after the treatment,systolic and diastolic blood pressure were significantly decreased,compared with that before treatment,the difference was statistically significant(P<0.05).At the end of treatment and 4 weeks after the end of treatment,in the irbesartan hydrochlorothiazide group,the systolic and diastolic blood pressure was significantly lower than that of the irbesartan group,and the difference was statistically significant(P<0.05).The two groups after treatment,urinary Alb and serum uric acid was significantly decreased,compared with before and after treatment,the difference was statistically significant(P<0.05),and irbesartan hydrochlorothiazide group was obviously better than irbesartan group,the difference was statistically significant(P<0.05).TC,BUN,TG and CR before and after treatment showed no statistical significance(P>0.05).Conclusion:Irbesartan hydrochlorothiazide tablets in the treatment of essential hypertension is better than irbesartan tablets.Clinically,irbesartan hydrochlorothiazide tablets should be the first choice for treatment.