CAJ | 학술논문

目的：研究肿瘤坏死因子（ TNF-α）在复发性口腔溃疡患者中的变化和病理改变，并讨论其临床意义。方法：选择复发性口腔溃疡患者112例，选择体检健康人29例作正常对照。血清TNF-α含量用双抗体夹心ELISA法测定，并对18例重型患者进行病理组织学检查。结果：复发性口腔溃疡患者血清TNF-α含量明显高于正常对照（56.2±16.7与26.3±11.2，P﹤0.01）。复发性口腔溃疡重型（69.7±29.2，P﹤0.01）和中型（65.1±14.4，P﹤0.01）明显高于轻型（39.1±17.6，P﹤0.01），即TNF-α含量重型﹥中型﹥轻型。18例组织病理学检查表明，14例以淋巴细胞、浆细胞及单核巨噬细胞浸润为主的炎性反应，4例为炎性反应伴有增生。结论：复发性口腔溃疡患者TNF-α含量可明显增高，病理改变是炎性反应或伴增生，提示TNF-α参与疾病的发生、发展过程。
목적：연구종류배사인자（ TNF-α）재복발성구강궤양환자중적변화화병리개변，병토론기림상의의。방법：선택복발성구강궤양환자112례，선택체검건강인29례작정상대조。혈청TNF-α함량용쌍항체협심ELISA법측정，병대18례중형환자진행병리조직학검사。결과：복발성구강궤양환자혈청TNF-α함량명현고우정상대조（56.2±16.7여26.3±11.2，P﹤0.01）。복발성구강궤양중형（69.7±29.2，P﹤0.01）화중형（65.1±14.4，P﹤0.01）명현고우경형（39.1±17.6，P﹤0.01），즉TNF-α함량중형﹥중형﹥경형。18례조직병이학검사표명，14례이림파세포、장세포급단핵거서세포침윤위주적염성반응，4례위염성반응반유증생。결론：복발성구강궤양환자TNF-α함량가명현증고，병리개변시염성반응혹반증생，제시TNF-α삼여질병적발생、발전과정。
To investigate the change of tumor necrosis factor - α( TNF - α)and histopatho1ogY in patients with recurrent ora1 u1cer,and discuss its c1inica1 significance. Methods 112 patients with recurrent ora1 u1cer. A medica1 hea1thY 29 cases were se1ected as norma1 contro1. Serums TNF - α 1eve1s were determined bY doub1e antibodY ELISA,and 18 severe patients were de1aminated bY patho_ 1ogica1 histo1ogY. Results In the patients with recurrent ora1 u1cer,serum TNF - α 1eve1s were significant1Y higher than norma1 contro1s (56. 2 ±16. 7 vs 26. 3 ±11. 2,P ﹤0. 01). TNF - α 1eve1s in severe(69. 7 ±29. 2,P ﹤0. 01)and moderate(65. 1 ±14. 4,P ﹤0. 01)pa_ tients were significant1Y higher than those of mi1d(39. 1 ±17. 6,P ﹤0. 01),and the severe patients ﹥ moderate ﹥ mi1d in TNF - α 1eve1s. Of 18 patients,patho1ogica1 histo1ogY showed that was inf1ammation inc1uding 1YmphocYtes,p1asma ce11s and mononuc1ear macrophage infi1_ tration in 14 cases,inf1ammation associated with pro1iferation in 4 cases. conclusion The resu1ts show that serum TNF - α 1eve1 can obvi_ ous1Y heighten in the patients with recurrent ora1 u1cer,and its patho1ogica1 changes are inf1ammation or with hYperp1asia,and TNF - α can invo1ve the deve1opment process in the recurrent ora1 u1cer