中国药品标准
中國藥品標準
중국약품표준
DRUG STANDARDS OF CHINA
2014年
6期
442-445
,共4页
贝美前列素滴眼液%抑菌效力%苯扎氯铵
貝美前列素滴眼液%抑菌效力%苯扎氯銨
패미전렬소적안액%억균효력%분찰록안
Bimatoprost Ophthalmic Solution%antibacterial effectiveness%benzalkonium chloride
目的：测定贝美前列素滴眼液中苯扎氯铵的抑菌效力，探索贝美前列素滴眼液中苯扎氯铵的合理添加剂量。方法：参照《中国药典》2010年版二部附录抑菌剂效力检查法指导原则的方法，对不同配比浓度苯扎氯铵的抑菌效果进行考察，筛选出适宜的抑菌剂加入量。结果：贝美前列素滴眼液中苯扎氯铵的处方量为0.006％时，对5种挑战微生物的抑菌效力均符合药典规定。结论：贝美前列素滴眼液中苯扎氯铵的处方量建议为0.006％。
目的：測定貝美前列素滴眼液中苯扎氯銨的抑菌效力，探索貝美前列素滴眼液中苯扎氯銨的閤理添加劑量。方法：參照《中國藥典》2010年版二部附錄抑菌劑效力檢查法指導原則的方法，對不同配比濃度苯扎氯銨的抑菌效果進行攷察，篩選齣適宜的抑菌劑加入量。結果：貝美前列素滴眼液中苯扎氯銨的處方量為0.006％時，對5種挑戰微生物的抑菌效力均符閤藥典規定。結論：貝美前列素滴眼液中苯扎氯銨的處方量建議為0.006％。
목적：측정패미전렬소적안액중분찰록안적억균효력，탐색패미전렬소적안액중분찰록안적합리첨가제량。방법：삼조《중국약전》2010년판이부부록억균제효력검사법지도원칙적방법，대불동배비농도분찰록안적억균효과진행고찰，사선출괄의적억균제가입량。결과：패미전렬소적안액중분찰록안적처방량위0.006％시，대5충도전미생물적억균효력균부합약전규정。결론：패미전렬소적안액중분찰록안적처방량건의위0.006％。
Objective:To determine the antimicrobial effectiveness of benzalkonium chlorideand explore the appropriate dosage of it in Bimatoprost Ophthalmic Solution.Methods:According to the guidance for antibacterial effectiveness test stated in appendix of Chinese Pharmacopoeia (the 2nd volume of 2010 edition), investigated the antimicrobial effect of samples with different dosage of benzalkonium chloride in the prescription and selected the appropriate dosage of antibacterial agent added.Results:The antimicrobial effects to all 5 challenge standard bacterial strains met the requirements of Chinese Pharmacopoeia when the concentration of benzalkonium chloride in Bimatoprost Ophthalmic Solutions reached 0.006%.Conclusion:Recommended concentration of benzalkonium chloride in Bimatoprost Ophthalmic Solution is 0.006%.
