南昌大学学报（医学版）
南昌大學學報（醫學版）
남창대학학보（의학판）
ACTA ACADEMIAE MEDICINAE JIANGXI
2014年
9期
22-25
,共4页
红细胞分布宽度%原发性高血压%阻塞性睡眠呼吸暂停综合征合并高血压
紅細胞分佈寬度%原髮性高血壓%阻塞性睡眠呼吸暫停綜閤徵閤併高血壓
홍세포분포관도%원발성고혈압%조새성수면호흡잠정종합정합병고혈압
red blood cell distribution width%primary hypertension%obstructive sleep apnea syndrome accompanied by hypertension
目的：探讨阻塞性睡眠呼吸暂停综合征（OSAS）合并高血压与红细胞分布宽度（RDW）的关系。方法选择2011年1月至2013年8月在中国人民解放军第九四医院呼吸内科门诊及住院的 OSAS 合并高血压患者（OSAS合并高血压组）44例和体检中心体检的原发性高血压患者（高血压组）57例、健康体检者（正常对照组）52例。各组清晨空腹抽取肘静脉血2 mL，用全自动五分类血细胞分析仪检测红细胞（RBC）计数、血红蛋白（Hb）、RDW 及白细胞（WBC）计数，比较各组 RDW 的差异，并进行相关性分析。结果高血压组 RBC 计数、Hb、RDW 和 WBC 计数与正常对照组比较差异均无统计学意义（均 P ＞0．05）；OSAS 合并高血压组 BMI、DBP、RBC 计数、Hb 和 RDW 均明显高于正常对照组、高血压组，SBP 明显高于正常对照组、明显低于高血压组（均 P ＜0．05）；高血压组 SBP、DBP均明显高于正常对照组（均 P ＜0．05）。相关性分析结果显示，OSAS 合并高血压组 RDW 与睡眠呼吸暂停低通气指数（AHI）呈正相关（r＝0．426，P ＜0．05），与最低氧饱和度呈负相关（r＝－0．509，P ＜0．05）。结论高血压患者RDW 无明显改变，RDW 增高可能是 OSAS 合并高血压患者心脑血管事件的标志物。
目的：探討阻塞性睡眠呼吸暫停綜閤徵（OSAS）閤併高血壓與紅細胞分佈寬度（RDW）的關繫。方法選擇2011年1月至2013年8月在中國人民解放軍第九四醫院呼吸內科門診及住院的 OSAS 閤併高血壓患者（OSAS閤併高血壓組）44例和體檢中心體檢的原髮性高血壓患者（高血壓組）57例、健康體檢者（正常對照組）52例。各組清晨空腹抽取肘靜脈血2 mL，用全自動五分類血細胞分析儀檢測紅細胞（RBC）計數、血紅蛋白（Hb）、RDW 及白細胞（WBC）計數，比較各組 RDW 的差異，併進行相關性分析。結果高血壓組 RBC 計數、Hb、RDW 和 WBC 計數與正常對照組比較差異均無統計學意義（均 P ＞0．05）；OSAS 閤併高血壓組 BMI、DBP、RBC 計數、Hb 和 RDW 均明顯高于正常對照組、高血壓組，SBP 明顯高于正常對照組、明顯低于高血壓組（均 P ＜0．05）；高血壓組 SBP、DBP均明顯高于正常對照組（均 P ＜0．05）。相關性分析結果顯示，OSAS 閤併高血壓組 RDW 與睡眠呼吸暫停低通氣指數（AHI）呈正相關（r＝0．426，P ＜0．05），與最低氧飽和度呈負相關（r＝－0．509，P ＜0．05）。結論高血壓患者RDW 無明顯改變，RDW 增高可能是 OSAS 閤併高血壓患者心腦血管事件的標誌物。
목적：탐토조새성수면호흡잠정종합정（OSAS）합병고혈압여홍세포분포관도（RDW）적관계。방법선택2011년1월지2013년8월재중국인민해방군제구사의원호흡내과문진급주원적 OSAS 합병고혈압환자（OSAS합병고혈압조）44례화체검중심체검적원발성고혈압환자（고혈압조）57례、건강체검자（정상대조조）52례。각조청신공복추취주정맥혈2 mL，용전자동오분류혈세포분석의검측홍세포（RBC）계수、혈홍단백（Hb）、RDW 급백세포（WBC）계수，비교각조 RDW 적차이，병진행상관성분석。결과고혈압조 RBC 계수、Hb、RDW 화 WBC 계수여정상대조조비교차이균무통계학의의（균 P ＞0．05）；OSAS 합병고혈압조 BMI、DBP、RBC 계수、Hb 화 RDW 균명현고우정상대조조、고혈압조，SBP 명현고우정상대조조、명현저우고혈압조（균 P ＜0．05）；고혈압조 SBP、DBP균명현고우정상대조조（균 P ＜0．05）。상관성분석결과현시，OSAS 합병고혈압조 RDW 여수면호흡잠정저통기지수（AHI）정정상관（r＝0．426，P ＜0．05），여최저양포화도정부상관（r＝－0．509，P ＜0．05）。결론고혈압환자RDW 무명현개변，RDW 증고가능시 OSAS 합병고혈압환자심뇌혈관사건적표지물。
Objective To explore the relationship between obstructive sleep apnea syndrome (OSAS)accompanied by hypertension and red blood cell distribution width(RDW).Methods Forty-four patients with OSAS accompanied by hypertension who were treated in the department of respiratory medicine in the 94th Hospital of the Chinese People’s Liberation Army from January 2011 to August 2013(OSAS accompanied by hypertension group)and 57 patients with primary hypertension(hypertension group)and 52 healthy physical examinees(normal control group)who were examined at physical examination center during the same period were selected in this study. Fasting venous blood samples(2 mL)were drawn and red blood cell(RBC)count,hemoglobin (Hb),RDW and white blood cell (WBC)count were detected by automatic five classification blood cell analyzer.The differences in RDW were compared among the three groups and the corre-lation analysis was performed.Results There were no significant differences in RBC count,Hb, RDW and WBC count between hypertension group and normal control group(P > 0.05).Com-pared with OSAS accompanied by hypertension group,body mass index(BMI),diastolic blood pressure(DBP),RBC count,Hb and RDW were reduced in both normal control group and hyper-tension group,and systolic blood pressure(SBP)was decreased in normal control group but was increased in hypertension group(P <0.05).Compared with normal control group,both SBP and DBP were increased in hypertension group(P <0.05).The correlation analysis showed that RDW was positively associated with the apnea hypopnea index(r=0.426,P <0.05)but was negatively associated with the lowest oxygen saturation(r=-0.509,P <0.05)in OSAS accompanied by hy-pertension group.Conclusion The RDW does not change obviously in patients with hyperten-sion.The increase in RDW may be a marker of cardiovascular and cerebrovascular events in pa-tients with OSAS accompanied by hypertension.
