CAJ | 학술논문

目的：探讨血脂康对糖尿病小鼠氧化应激的影响。方法取6～8周龄的 BALB／c 雄性小鼠腹腔注射链脲佐菌素建立糖尿病模型，建模成功后随机分为非治疗组（5％阿拉伯胶，n＝6）和血脂康组（200 mg·kg－1·d－1，n＝6），腹腔注射相应药物，1次·d－1，连续4周；另设正常对照组（n＝6）进行比较，检测各组小鼠建模成功后血糖水平及给药前，给药4周后尿液中8-异前列腺素（8-isoprostane）浓度。结果与正常对照组比较，非治疗组和血脂康组血糖值均明显升高（P ＜0．001），但2组间比较差异无统计学意义（P ＞0．05）；给药4周后，与正常对照组比较，非治疗组尿液中8-isoprostane 浓度明显升高（P ＜0．05），但血脂康组与正常对照组比较差异无统计学意义（P ＞0．05）。结论糖尿病小鼠体内氧化应激有所增强，血脂康具有一定抗氧化应激作用。
목적：탐토혈지강대당뇨병소서양화응격적영향。방법취6～8주령적 BALB／c 웅성소서복강주사련뇨좌균소건립당뇨병모형，건모성공후수궤분위비치료조（5％아랍백효，n＝6）화혈지강조（200 mg·kg－1·d－1，n＝6），복강주사상응약물，1차·d－1，련속4주；령설정상대조조（n＝6）진행비교，검측각조소서건모성공후혈당수평급급약전，급약4주후뇨액중8-이전렬선소（8-isoprostane）농도。결과여정상대조조비교，비치료조화혈지강조혈당치균명현승고（P ＜0．001），단2조간비교차이무통계학의의（P ＞0．05）；급약4주후，여정상대조조비교，비치료조뇨액중8-isoprostane 농도명현승고（P ＜0．05），단혈지강조여정상대조조비교차이무통계학의의（P ＞0．05）。결론당뇨병소서체내양화응격유소증강，혈지강구유일정항양화응격작용。
Objective To study the effect of Xuezhikang on oxidative stress of diabetic mice. Methods A diabetic model was established in 6-8-week-old male BALB/c mice by intraperitoneal injection of streptozotocin.Then,diabetic mice were intraperitoneally injected with either 5%Ara-bic gum(non-therapy group,n=6)or Xuezhikang 200 mg·kg-1 ·d-1 (Xuezhikang group,n=6) once per day for 4 weeks.In addition,health mice were selected as the normal control group(n=6).The levels of blood glucose were detected after successful modeling and urinary concentrations of 8-isoprostane were determined before and after treatment for 4 weeks.Results Compared with normal control group,the levels of blood glucose were significantly increased in both non-therapy group and Xuezhikang group(P <0.001),and urinary concentrations of 8-isoprostane were obvi-ously elevated in non-therapy group after treatment for 4 weeks(P <0.05).However,there were no significant differences in blood glucose levels between non-therapy group and Xuezhikang group,as well as in urinary 8-isoprostane concentrations between Xuezhikang group and normal control group(P > 0.05).Conclusion Diabetes mellitus leads to increased oxidative stress in mice and Xuezhikang reduces oxidative stress in diabetic mice.