CAJ | 학술논문

目的：探讨老年性痴呆（AD）危险因素之间可能存在的交互作用。方法通过病例对照研究获得老年性痴呆的主要影响因素，然后采用相加模型分析主要影响因素之间的交互作用。结果Logistic 回归分析显示，年龄（OR＝1．069）、文化程度（OR＝0．601）、脑血管病史（OR＝3．660）、血铝水平（OR ＝3．739）、血硒水平（OR ＝0．611）为 AD 的主要影响因素。在对年龄进行调整后，交互作用超额相对危险度（RERI）为6．877，交互作用归因比（API）为59．52％，交互作用指数（S）为2．870。结论血铝水平和脑血管病史在 AD 的患病中可能存在正交互作用。
목적：탐토노년성치태（AD）위험인소지간가능존재적교호작용。방법통과병례대조연구획득노년성치태적주요영향인소，연후채용상가모형분석주요영향인소지간적교호작용。결과Logistic 회귀분석현시，년령（OR＝1．069）、문화정도（OR＝0．601）、뇌혈관병사（OR＝3．660）、혈려수평（OR ＝3．739）、혈서수평（OR ＝0．611）위 AD 적주요영향인소。재대년령진행조정후，교호작용초액상대위험도（RERI）위6．877，교호작용귀인비（API）위59．52％，교호작용지수（S）위2．870。결론혈려수평화뇌혈관병사재 AD 적환병중가능존재정교호작용。
Objective To explore the interaction of risk factors for Alzheimer’s disease (AD). Methods The main risk factors for AD were obtained by case-control study and the interaction of risk factors was analyzed by additive model.Results Logistic regression analysis indicated that age (OR = 1.069),education degree (OR = 0.601 ),history of cerebrovascular disease (OR =3.660),blood aluminum level (OR=3.739)and blood selenium level (OR=0.611)were the main risks factors for AD.After adjusting the influence of age,the relative excess risk due to interac-tion,attributable proportion due to interaction and synergy index were 6.877,59.52% and 2.870, respectively.Conclusion There is a synergism interaction between blood aluminum level and his-tory of cerebrovascular disease in AD.