南昌大学学报（医学版）
南昌大學學報（醫學版）
남창대학학보（의학판）
ACTA ACADEMIAE MEDICINAE JIANGXI
2014年
10期
33-36
,共4页
代谢综合征%血清尿酸%超敏 C 反应蛋白%白细胞介素-6%西宁,青海
代謝綜閤徵%血清尿痠%超敏 C 反應蛋白%白細胞介素-6%西寧,青海
대사종합정%혈청뇨산%초민 C 반응단백%백세포개소-6%서저,청해
metabolic syndrome%serum uric acid%high-sensitive C-reactive protein%interleukin-6%Xining,Qinghai
目的：探讨青海西宁地区汉、藏族代谢综合征（MS）患者高血清尿酸（SUA）水平的影响因素。方法将335例 MS 患者根据 SUA 水平与种族不同分为4组：汉族 MS 伴正常 SUA 组（A 组）98例、汉族 MS 伴高 SUA 组（B 组）111例、藏族 MS 伴正常 SUA 组（C 组）64例及藏族 MS 伴高 SUA 组（D 组）62例。收集患者的一般资料，包括：年龄、身高、体质量及体质量指数（BMI）；并采集静脉血行相关生化指标检测，包括空腹血糖（FBG）、总胆固醇（TC）、甘油三酯（TG）、低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-C）、载脂蛋白 AI（apo AI）、载脂蛋白 B（apo B）、尿酸（UA）、超敏 C 反应蛋白（hs-CRP）及白细胞介素-6（IL-6）。结果B 组的年龄、BMI、FBG、TC、TG、LDL-C、apo AI、apo B、hs-CRP 及 IL-6均较 A 组显著增加（P ＜0．05），D 组的年龄、BMI、FBG、TC、TG、LDL-C、apo AI、apo B、hs-CRP 及 IL-6均较 C 组显著增加（P ＜0．05）；B 组与 D 组的 BMI、FBG、TC、TG、LDL-C、apo B、hs-CRP 及 IL-6相比差异均有统计学意义（P ＜0．05）。Logistic 回归分析结果显示，汉族 MS 患者高 SUA 的影响因素有：BMI、FBG、TC、TG、LDL-C、apoB、hs-CRP 及 IL-6，藏族 MS 患者高 SUA 的影响因素有：年龄、BMI、FBG、TC、TG、LDL-C、apoB、hs-CRP 及 IL-6。结论青海西宁地区汉、藏族 MS 患者高 SUA 水平与 BMI、FBG、TC、hs-CRP 及 IL-6相关；藏族人群在 MS 的预防过程中应该更注重 SUA 水平的控制。
目的：探討青海西寧地區漢、藏族代謝綜閤徵（MS）患者高血清尿痠（SUA）水平的影響因素。方法將335例 MS 患者根據 SUA 水平與種族不同分為4組：漢族 MS 伴正常 SUA 組（A 組）98例、漢族 MS 伴高 SUA 組（B 組）111例、藏族 MS 伴正常 SUA 組（C 組）64例及藏族 MS 伴高 SUA 組（D 組）62例。收集患者的一般資料，包括：年齡、身高、體質量及體質量指數（BMI）；併採集靜脈血行相關生化指標檢測，包括空腹血糖（FBG）、總膽固醇（TC）、甘油三酯（TG）、低密度脂蛋白膽固醇（LDL-C）、高密度脂蛋白膽固醇（HDL-C）、載脂蛋白 AI（apo AI）、載脂蛋白 B（apo B）、尿痠（UA）、超敏 C 反應蛋白（hs-CRP）及白細胞介素-6（IL-6）。結果B 組的年齡、BMI、FBG、TC、TG、LDL-C、apo AI、apo B、hs-CRP 及 IL-6均較 A 組顯著增加（P ＜0．05），D 組的年齡、BMI、FBG、TC、TG、LDL-C、apo AI、apo B、hs-CRP 及 IL-6均較 C 組顯著增加（P ＜0．05）；B 組與 D 組的 BMI、FBG、TC、TG、LDL-C、apo B、hs-CRP 及 IL-6相比差異均有統計學意義（P ＜0．05）。Logistic 迴歸分析結果顯示，漢族 MS 患者高 SUA 的影響因素有：BMI、FBG、TC、TG、LDL-C、apoB、hs-CRP 及 IL-6，藏族 MS 患者高 SUA 的影響因素有：年齡、BMI、FBG、TC、TG、LDL-C、apoB、hs-CRP 及 IL-6。結論青海西寧地區漢、藏族 MS 患者高 SUA 水平與 BMI、FBG、TC、hs-CRP 及 IL-6相關；藏族人群在 MS 的預防過程中應該更註重 SUA 水平的控製。
목적：탐토청해서저지구한、장족대사종합정（MS）환자고혈청뇨산（SUA）수평적영향인소。방법장335례 MS 환자근거 SUA 수평여충족불동분위4조：한족 MS 반정상 SUA 조（A 조）98례、한족 MS 반고 SUA 조（B 조）111례、장족 MS 반정상 SUA 조（C 조）64례급장족 MS 반고 SUA 조（D 조）62례。수집환자적일반자료，포괄：년령、신고、체질량급체질량지수（BMI）；병채집정맥혈행상관생화지표검측，포괄공복혈당（FBG）、총담고순（TC）、감유삼지（TG）、저밀도지단백담고순（LDL-C）、고밀도지단백담고순（HDL-C）、재지단백 AI（apo AI）、재지단백 B（apo B）、뇨산（UA）、초민 C 반응단백（hs-CRP）급백세포개소-6（IL-6）。결과B 조적년령、BMI、FBG、TC、TG、LDL-C、apo AI、apo B、hs-CRP 급 IL-6균교 A 조현저증가（P ＜0．05），D 조적년령、BMI、FBG、TC、TG、LDL-C、apo AI、apo B、hs-CRP 급 IL-6균교 C 조현저증가（P ＜0．05）；B 조여 D 조적 BMI、FBG、TC、TG、LDL-C、apo B、hs-CRP 급 IL-6상비차이균유통계학의의（P ＜0．05）。Logistic 회귀분석결과현시，한족 MS 환자고 SUA 적영향인소유：BMI、FBG、TC、TG、LDL-C、apoB、hs-CRP 급 IL-6，장족 MS 환자고 SUA 적영향인소유：년령、BMI、FBG、TC、TG、LDL-C、apoB、hs-CRP 급 IL-6。결론청해서저지구한、장족 MS 환자고 SUA 수평여 BMI、FBG、TC、hs-CRP 급 IL-6상관；장족인군재 MS 적예방과정중응해경주중 SUA 수평적공제。
Objective To investigate the factors influencing high serum uric acid(SUA)levels in Han and Tibetan patients with metabolic syndrome(MS)in Xining City of Qinghai Province. Methods A total of 335 MS patients were divided into four groups:Han MS patients with normal SUA levels(group A,n=98),Han MS patients with high SUA levels(group B,n=111),Tibetan MS patients with normal SUA levels(group C,n=64),and Tibetan MS patients with high SUA levels(group D,n=62).General data of patients were collected,including age,height,weight and body mass index(BMI).In addition,venous blood samples were drawn for the detection of bio-chemical indices,including fasting blood glucose(FBG),total cholesterol(TC),triglyceride(TG), low-density lipoprotein cholesterol(LDL-C),high-density lipoprotein cholesterol(HDL-C),apoli-poprotein AI(apo AI),apolipoprotein B(apo B),uric acid(UA),high sensitivity C-reactive protein (hs-CRP)and interleukin-6 (IL-6).Results Compared with group A,the age,BMI,FBG,TC, TG,LDL-C,apo AI,apo B,hs-CRP and IL-6 significantly increased in group B(P <0.05).Com-pared with group C,the age,BMI,FBG,TC,TG,LDL-C,apo AI,apo B,hs-CRP and IL-6 signifi-cantly increased in group D(P <0.05).There were obvious differences in the BMI,FBG,TC,TG, LDL-C,apo B,hs-CRP and IL-6 between group B and group D(P <0.05).Logistic regression a-nalysis showed that BMI,FBG,TC,TG,LDL-C,apoB,hs-CRP and IL-6 were the factors influen-cing high SUA levels in Han patients with MS and the age,BMI,FBG,TC,TG,LDL-C,apoB,hs-CRP and IL-6 were the factors influencing high SUA levels in Tibetan patients with MS.Conclu-sion The BMI,FBG,TC,hs-CRP and IL-6 were correlated with high SUA levels in Han and Ti-betan patients with MS in Xining City of Qinghai Province.More attention should be paid to the control of SUA levels during the prevention of MS in Tibetan population.
