CAJ | 학술논문

目的：：探讨氨氯地平联合阿托伐他汀治疗老年急性脑梗死高血压的临床疗效。方法：86例急性脑梗死高血压患者随机分为观察组与对照组,每组43例。对照组给予苯磺酸氨氯地平片5 mg,po,qd,观察组在对照组基础上加用阿托伐他汀片20 mg,po,qd。治疗1个月后比较两组患者疗效及神经功能缺损评分、血压、血脂、C反应蛋白( CRP)等指标变化情况。结果：治疗后,观察组急性脑梗死总有效率明显高于对照组(P<0.05)；降压总有效率明显优于对照组(P<0.05)。治疗后两组神经功能缺损评分均明显高于治疗前(P<0.05),且观察组评分明显高于对照组(P<0.05)。两组患者血压均较前明显降低(P<0.05),且观察组较对照组下降更明显(P<0.05)。治疗后观察组TC、TG、LDL-C和CRP等指标水平较治疗前明显降低(P<0.05),也明显低于对照组(P<0.05)。结论：使用氨氯地平联合阿托伐他汀治疗老年急性脑梗死高血压,效果显著,不良反应少,值得推广应用。
목적：：탐토안록지평연합아탁벌타정치료노년급성뇌경사고혈압적림상료효。방법：86례급성뇌경사고혈압환자수궤분위관찰조여대조조,매조43례。대조조급여분광산안록지평편5 mg,po,qd,관찰조재대조조기출상가용아탁벌타정편20 mg,po,qd。치료1개월후비교량조환자료효급신경공능결손평분、혈압、혈지、C반응단백( CRP)등지표변화정황。결과：치료후,관찰조급성뇌경사총유효솔명현고우대조조(P<0.05)；강압총유효솔명현우우대조조(P<0.05)。치료후량조신경공능결손평분균명현고우치료전(P<0.05),차관찰조평분명현고우대조조(P<0.05)。량조환자혈압균교전명현강저(P<0.05),차관찰조교대조조하강경명현(P<0.05)。치료후관찰조TC、TG、LDL-C화CRP등지표수평교치료전명현강저(P<0.05),야명현저우대조조(P<0.05)。결론：사용안록지평연합아탁벌타정치료노년급성뇌경사고혈압,효과현저,불량반응소,치득추엄응용。
Objective:To discuss the effect of amlodipine combined with atorvastatin in the treatment of elderly patients with acute cerebral infarction hypertension. Methods:Totally 86 cases with acute cerebral infarction hypertension were randomly divided into the treatment group (43 cases) and the control group (43 cases). The control group received amlodipine 5mg, po, qd, and the treatment group was given atorvastatin 20mg additionally, po, qd. After the one-month treatment, the efficacy of the two groups was studied and compared, and the changes in neural function defect scale, blood pressure, blood lipids and CRP were also investigated. Results:Af-ter the treatment, the total effective rate and the total effective rate of antihypertensive effect in the treatment group were both signifi-cantly higher than those in the control group (P<0. 05). The neurological deficit scores of the two groups were significantly higher than those before the treatment (P<0. 05), and those of the observation group was significantly higher than those of the control group (P<0. 05). The blood pressure of the two groups was both decreased after the treatment(P<0. 05), and the decrease in the treat-ment group was more significant (P<0. 05). TC, TG, LDL-C and CRP levels of the two groups had significant decrease after the treatment (P>0. 05), and those in the treatment group was significant lower than those in the control group (P<0. 05). Conclu-sion:Amlodipine combined atorvastatin in the treatment of elderly patients with acute cerebral infarction hypertension shows significant effect with low incidence of adverse drug reaction, which is worthy of wider application.