CAJ | 학술논문

目的：：建立电感耦合等离子体质谱法( ICP-MS)测定注射用水中镁、铝、铬、铜、锌、砷、镉、锡、钡、铅、钙、钾、硒、银、钠、汞等16种元素含量的方法。方法：采用ICP-MS法碰撞池技术( CCT)，最大程度的减少多原子干扰，通过在线加入锂、钪、锗、铟、铱、铋内标液的方法校正由于基体效应和信号漂移对测量所造成的影响，样品直接酸化测定注射用水中的16种金属元素的含量。结果： ICP-MS技术测定16种金属元素的检测限范围为0.009~0.165 ng·ml-1；标准曲线线性关系良好( r≥0.9990)；回收率均在80%~120%范围之内(n=6)。结论：上述方法简便、快速、准确，可用于注射用水中16种金属元素含量的测定，并以此降低注射用水中存在毒性较大金属元素含量超标的潜在风险，为注射用水更严格的质量控制提供参考。
목적：：건립전감우합등리자체질보법( ICP-MS)측정주사용수중미、려、락、동、자、신、력、석、패、연、개、갑、서、은、납、홍등16충원소함량적방법。방법：채용ICP-MS법팽당지기술( CCT)，최대정도적감소다원자간우，통과재선가입리、항、타、인、의、필내표액적방법교정유우기체효응화신호표이대측량소조성적영향，양품직접산화측정주사용수중적16충금속원소적함량。결과： ICP-MS기술측정16충금속원소적검측한범위위0.009~0.165 ng·ml-1；표준곡선선성관계량호( r≥0.9990)；회수솔균재80%~120%범위지내(n=6)。결론：상술방법간편、쾌속、준학，가용우주사용수중16충금속원소함량적측정，병이차강저주사용수중존재독성교대금속원소함량초표적잠재풍험，위주사용수경엄격적질량공제제공삼고。
Objective:To establish the methods for the determination of Mg,Al,K,Ca,Cr,Cu,Zn,As,Se,Ag,Cd,Sn,Ba,Pb,Na and Hg in water for injection. Methods:The sixteen metallic elements in water for injection were determined by ICP-MS. The collision cell technology ( CCT) was used to minimize the multiple atomic interference, and the matrix effect and signal drift were compensated by using Li, Sc, Ge, In, Ir and Bi as the internal standards and the samples were directly acidified to detect the metallic elements. Results:The detection limit range of the 16 metallic elements were from 0. 009 to 0. 165 ng·ml-1. The calibration curves showed good linearity (r≥0. 999 0). The recoveries were within the range of 80%-120%(n=6). Conclusion:The method is simple, rapid and accurate. It can be used to determine the contents of metallic elements to reduce the potential exceeding limit risk of toxic metal el-ements in water for injection. The methods also can provide reference for the more strict quality evaluation of water for injection.