CAJ | 학술논문

目的：：优化甲冰缓释膜的处方。方法：以白及多糖与聚乙烯醇124( PVA-124)的质量比、甘油和羧甲基纤维素钠(CMC-Na)的用量为考察因素,以膜剂的外观、0.5 h与4 h甲硝唑的释放度为综合评价指标,采用正交试验对成膜材料的处方进行优化。结果：白及多糖与PVA124的用量比例是影响膜剂质量的关键因素,当白及多糖与PVA124的质量比为20∶80、甘油用量为3.5 g、CMC-Na用量为0.14 g时,所制得的膜剂外观符合要求,0.5 h及4 h的释放度分别为25.17%、69.64%,8 h平均累积释放率>90%。结论：经优化的处方所制成的药膜平整光洁,柔软度适中,即能保持原处方透膜释放药物的特性,又能发挥白及的药理作用。
목적：：우화갑빙완석막적처방。방법：이백급다당여취을희순124( PVA-124)적질량비、감유화최갑기섬유소납(CMC-Na)적용량위고찰인소,이막제적외관、0.5 h여4 h갑초서적석방도위종합평개지표,채용정교시험대성막재료적처방진행우화。결과：백급다당여PVA124적용량비례시영향막제질량적관건인소,당백급다당여PVA124적질량비위20∶80、감유용량위3.5 g、CMC-Na용량위0.14 g시,소제득적막제외관부합요구,0.5 h급4 h적석방도분별위25.17%、69.64%,8 h평균루적석방솔>90%。결론：경우화적처방소제성적약막평정광길,유연도괄중,즉능보지원처방투막석방약물적특성,우능발휘백급적약리작용。
Objective:To optimize the formula of metronidazole and borneol sustained-release films. Methods: The mass ratio of Rhizoma Bletillae polysaccharide and polyvinyl alcohol 124(PVA-124) and the dosage of glycerol and sodium carboxymethyl cellulose ( CMC-Na) as the influencing factors ,the appearance of films and the release rate of metronidazole at 0. 5h and 4h as the comprehen-sive evaluation indices, the formula of the film-forming materials was optimized by orthogonal test. Results:The mass ratio of Rhizoma Bletillae polysaccharide and PVA-124 was the key factor affecting the quality of the films. When the mass ratio of Rhizoma Bletillae pol-ysaccharide and PVA-124 was 20∶80, and the dosage of glycerol was 3. 5g and that of CMC-Na was 0. 14g, the appearance of the films was satisfied, the release rate of metronidazole at 0. 5h and 4h was 25. 17% and 69. 64%, respectively, and the average cumulative re-lease rate at 8h was over 90%. Conclusion:The films prepared by the optimized formula are flat, smooth, clean and moderately soft, which can not only remain the drug release characteristics of the films made by the original formula, but also exhibit the pharmacologi-cal effect of Rhizoma Bletillae.