中国药师
中國藥師
중국약사
CHINA PHARMACIST
2014年
12期
2019-2021
,共3页
邻苯二甲酸二丁酯%精子%睾丸%附睾%大鼠
鄰苯二甲痠二丁酯%精子%睪汍%附睪%大鼠
린분이갑산이정지%정자%고환%부고%대서
Dibutyl phthalate%Sperm%Testes%Epididymides%Rats
目的：：探讨邻苯二甲酸二丁酯( DBP)对大鼠精子的生成和质量影响。方法：150只雄性大鼠,随机分为DBP低剂量组(50 mg·kg-1)、DBP中剂量组(200 mg·kg-1)、DBP高剂量组(1000 mg·kg-1)、空白对照组(蒸馏水)和溶剂对照组(花生油),每组30只,每天灌胃给药,每30d每组取10只大鼠解剖取样,称量睾丸、附睾质量,取一侧附睾进行精子计数、精子存活率和精子形态分析。结果：灌胃90 d,DBP中、高剂量组精子数、精子存活率、睾丸、附质重量及其脏器系数均明显降低( P<0.05或0.01)。结论：长期大剂量使用DBP对大鼠生殖功能有毒性作用。
目的：：探討鄰苯二甲痠二丁酯( DBP)對大鼠精子的生成和質量影響。方法：150隻雄性大鼠,隨機分為DBP低劑量組(50 mg·kg-1)、DBP中劑量組(200 mg·kg-1)、DBP高劑量組(1000 mg·kg-1)、空白對照組(蒸餾水)和溶劑對照組(花生油),每組30隻,每天灌胃給藥,每30d每組取10隻大鼠解剖取樣,稱量睪汍、附睪質量,取一側附睪進行精子計數、精子存活率和精子形態分析。結果：灌胃90 d,DBP中、高劑量組精子數、精子存活率、睪汍、附質重量及其髒器繫數均明顯降低( P<0.05或0.01)。結論：長期大劑量使用DBP對大鼠生殖功能有毒性作用。
목적：：탐토린분이갑산이정지( DBP)대대서정자적생성화질량영향。방법：150지웅성대서,수궤분위DBP저제량조(50 mg·kg-1)、DBP중제량조(200 mg·kg-1)、DBP고제량조(1000 mg·kg-1)、공백대조조(증류수)화용제대조조(화생유),매조30지,매천관위급약,매30d매조취10지대서해부취양,칭량고환、부고질량,취일측부고진행정자계수、정자존활솔화정자형태분석。결과：관위90 d,DBP중、고제량조정자수、정자존활솔、고환、부질중량급기장기계수균명현강저( P<0.05혹0.01)。결론：장기대제량사용DBP대대서생식공능유독성작용。
Objective:To evaluate the effects of dibutyl phthalate on rat sperm production and quality. Methods:Totally 150 male rats were randomly divided into the low dose group (50 mg·kg-1), the middle dose group (200 mg·kg-1), the high dose group (1 000 mg·kg-1 ) , the blank control group and the solvent control group ( peanut oil as the control) with 30 ones in each. After continu-ous administration for every 30 days, 10 rats from each group were anatomized, the weight of testes and epididymides were determined, and one side of epididymis was used to carry out the sperm analysis including counting, survival rate and morphology. Results:After intragastric administration for 90 days, the sperm count and survival rate, the weight of testis and epididymis and organ coefficient in the middle dose group and high dose group were decreased significantly(P<0. 05 or 0. 01). Conclusion:The long-term administration of dibutyl phthalate at high dose exhibits notable toxicity on rat reproductive function.
