CAJ | 학술논문

目的：探讨骨折延迟愈合患者血清可溶性细胞间黏附分子（ sICAM－1）、血管细胞黏附分子（VCAM－1）、骨形态发生蛋白2（BMP－2）及微循环指标的变化情况。方法50例骨折延迟愈合（A组），50例骨折正常愈合者（ B组），50例健康志愿者（ C组），检测3组血清sICAM－1、VCAM－1、BMP－2水平及红细胞聚集、血液流变学指标。结果 A 组血清sICAM－1、VCAM－1均高于B 组及C 组，而血清BMP－2则低于B 组、C 组（P＜0．05）；A组的红细胞聚集程度低于B组及C组（P＜0．05）；A组的全血低切黏度、血浆黏度、红细胞电泳指数均高于B组及C组（P均＜0．05）。结论骨折延迟愈合患者血清sICAM－1、VCAM－1水平升高，BMP－2水平降低，并且微循环状态较差，积极干预可避免或者降低高危人群发生骨折延迟愈合的风险。
목적：탐토골절연지유합환자혈청가용성세포간점부분자（ sICAM－1）、혈관세포점부분자（VCAM－1）、골형태발생단백2（BMP－2）급미순배지표적변화정황。방법50례골절연지유합（A조），50례골절정상유합자（ B조），50례건강지원자（ C조），검측3조혈청sICAM－1、VCAM－1、BMP－2수평급홍세포취집、혈액류변학지표。결과 A 조혈청sICAM－1、VCAM－1균고우B 조급C 조，이혈청BMP－2칙저우B 조、C 조（P＜0．05）；A조적홍세포취집정도저우B조급C조（P＜0．05）；A조적전혈저절점도、혈장점도、홍세포전영지수균고우B조급C조（P균＜0．05）。결론골절연지유합환자혈청sICAM－1、VCAM－1수평승고，BMP－2수평강저，병차미순배상태교차，적겁간예가피면혹자강저고위인군발생골절연지유합적풍험。
Objective To investigate the changes in serum soluble intercellular adhesion molecule-1(sICAM-1), vascular cell adhesion molecule-1(VCAM-1),bone morphogenetic protein-2(BMP-2) and microcirculation indexes of patients with delayed fracture healing .Methods Fifty patients with delayed fracture healing ( group A ) ,50 patients with normal fracture healing ( group B ) , and 50 healthy people ( group C ) were enrolled in the study .The serum sICAM-1,sVCAM-1,BMP-2 and the indexes of erythrocyte aggregation and hemorheology were detected among three groups .Results The serum levels of sICAM-1 and VCAM-1 in group A were higher than those of group B and group C , but the serum BMP-2 level was lower than those of group B and group C ( P<0.05) .The erythrocyte aggregation rate in group A was lower than those of group B and group C ( P <0.05 ) .The whole blood viscosity , plasma viscosity and erythrocyte electrophoresis index in group A were higer than those of group B and group C (all P<0.05).Conclusion The serum sICAM-1 and VCAM-1 levels increase but BMP-2 level decreases in patients with delayed fracture healing , with worse microcirculation .Active intervention could benefit avoiding or decreasing the risk of delayed fracture healing in high-risk population .