CAJ | 학술논문

目的：评价吡西卡尼治疗心房颤动的有效性及安全性。方法计算机检索PubMed、EMbase和Cochrane Library数据库，查找所有有关吡西卡尼治疗心房颤动的临床随机对照试验（ RCT），检索时限均为建库至2013年12月31日。由两名研究者按照纳入与排除标准独立筛选文献、提取资料和评价质量后，进行Meta分析。结果共纳入5个研究，376例患者。 Meta 分析结果显示：吡西卡尼组房颤转复率高于对照组（P＝0．03）；吡西卡尼治疗阵发性房颤、持续性房颤均表现出优势，但与对照组相比，两组房颤转复率差异均无统计学意义（P＜0．05）；两组药物不良反应发生率差异无统计学意义（P＞0．05）。结论吡西卡尼治疗房颤疗效确切，不良反应少。
목적：평개필서잡니치료심방전동적유효성급안전성。방법계산궤검색PubMed、EMbase화Cochrane Library수거고，사조소유유관필서잡니치료심방전동적림상수궤대조시험（ RCT），검색시한균위건고지2013년12월31일。유량명연구자안조납입여배제표준독립사선문헌、제취자료화평개질량후，진행Meta분석。결과공납입5개연구，376례환자。 Meta 분석결과현시：필서잡니조방전전복솔고우대조조（P＝0．03）；필서잡니치료진발성방전、지속성방전균표현출우세，단여대조조상비，량조방전전복솔차이균무통계학의의（P＜0．05）；량조약물불량반응발생솔차이무통계학의의（P＞0．05）。결론필서잡니치료방전료효학절，불량반응소。
Objective To assess the effectiveness and safety of pilsicainide in the treatment of atrial fibrillation (AF).Methods All randomized controlled trials (RCTs) on pilsicainide for the treatment of AF were retrieved from databases including PubMed ,EMbase and Cochrane Library ,the time ranged from the date of databases′initial construction to December 31,2013.The data extraction,based on the inclusion and exclusion criteria ,and quality assessment of included RCTs were conducted by two reviewers independently .And then a Meta-analysis was conducted .Results Five RCTs involving 376 patients were included .The results of Meta-analysis were as follows .The successful conversion rate of pilsicainide group was superior to that of control group ( P=0 .03 ) .Pilsicainide showed higher successful conversion rates of paroxysmal AF and persistent AF compared with the controls ,but there were no statistical differences between two groups(P>0.05).No significant difference was observed in the incidence of adverse drug reactions between two groups(P>0.05).Conclusion Pilsicainide is effective in the treatment of AF,with less adverse reactions.