广西医学
廣西醫學
엄서의학
GUANGXI MEDICAL JOURNAL
2014年
11期
1538-1541
,共4页
林英忠%王虹%金献萍%马春兰
林英忠%王虹%金獻萍%馬春蘭
림영충%왕홍%금헌평%마춘란
心肌梗死%急性ST段抬高型%microRNA-92 a%地奥心血康软胶囊%循环
心肌梗死%急性ST段抬高型%microRNA-92 a%地奧心血康軟膠囊%循環
심기경사%급성ST단태고형%microRNA-92 a%지오심혈강연효낭%순배
Myocardial infarction%Acute ST-segment elevation%microRNA 92 a%Di′ao Xinxuekang soft capsule%Circulation
目的:探讨地奥心血康软胶囊对急性ST段抬高型心肌梗死(STEMI)患者循环微RNA-92a(miR-92a)表达的影响。方法 STEMI患者50例按随机数字表法分为对照组和治疗组,每组25例,两组患者均在急诊经皮冠状动脉介入治疗( PCI)后给予常规药物治疗,治疗组在此基础上加用地奥心血康软胶囊,对照组未加用地奥心血康软胶囊。对比两组患者常规药物治疗前和治疗4周后循环miR-92a表达量、左室射血分数(LVEF)变化。结果治疗后治疗组miR-92a表达量水平明显低于治疗前(P<0.05),亦低于对照组治疗后(P<0.05)。治疗后两组LVEF均明显高于治疗前(P<0.05),治疗前、治疗后两组LVEF分别比较,差异均无统计学意义(P>0.05)。治疗后随访3个月,治疗组主要不良心脏事件(MACEs)发生率为13.0%,对照组为34.8%,两组比较差异无统计学意义(P>0.05)。结论 STEMI患者PCI后应用地奥心血康软胶囊治疗,可下调外周血循环miR-92 a表达水平,未增加MACEs发生率,无明显不良反应。
目的:探討地奧心血康軟膠囊對急性ST段抬高型心肌梗死(STEMI)患者循環微RNA-92a(miR-92a)錶達的影響。方法 STEMI患者50例按隨機數字錶法分為對照組和治療組,每組25例,兩組患者均在急診經皮冠狀動脈介入治療( PCI)後給予常規藥物治療,治療組在此基礎上加用地奧心血康軟膠囊,對照組未加用地奧心血康軟膠囊。對比兩組患者常規藥物治療前和治療4週後循環miR-92a錶達量、左室射血分數(LVEF)變化。結果治療後治療組miR-92a錶達量水平明顯低于治療前(P<0.05),亦低于對照組治療後(P<0.05)。治療後兩組LVEF均明顯高于治療前(P<0.05),治療前、治療後兩組LVEF分彆比較,差異均無統計學意義(P>0.05)。治療後隨訪3箇月,治療組主要不良心髒事件(MACEs)髮生率為13.0%,對照組為34.8%,兩組比較差異無統計學意義(P>0.05)。結論 STEMI患者PCI後應用地奧心血康軟膠囊治療,可下調外週血循環miR-92 a錶達水平,未增加MACEs髮生率,無明顯不良反應。
목적:탐토지오심혈강연효낭대급성ST단태고형심기경사(STEMI)환자순배미RNA-92a(miR-92a)표체적영향。방법 STEMI환자50례안수궤수자표법분위대조조화치료조,매조25례,량조환자균재급진경피관상동맥개입치료( PCI)후급여상규약물치료,치료조재차기출상가용지오심혈강연효낭,대조조미가용지오심혈강연효낭。대비량조환자상규약물치료전화치료4주후순배miR-92a표체량、좌실사혈분수(LVEF)변화。결과치료후치료조miR-92a표체량수평명현저우치료전(P<0.05),역저우대조조치료후(P<0.05)。치료후량조LVEF균명현고우치료전(P<0.05),치료전、치료후량조LVEF분별비교,차이균무통계학의의(P>0.05)。치료후수방3개월,치료조주요불양심장사건(MACEs)발생솔위13.0%,대조조위34.8%,량조비교차이무통계학의의(P>0.05)。결론 STEMI환자PCI후응용지오심혈강연효낭치료,가하조외주혈순배miR-92 a표체수평,미증가MACEs발생솔,무명현불량반응。
Objective To investigate the effect of Di′ao Xinxuekang soft capsule on circulating microRNA-92 a ( miR-92 a) expression in patients with acute ST-segment elevation myocardial infarction ( STEMI ) .Methods Fifty patients with STEMI were divided into two groups randomly ,control group ( n=25 ) and therapy group ( n=25 ) .Both groups underwent emergency percutaneous coronary intervention ( PCI ) and conventional therapy .The control group was given Di′ao Xinxuekang soft capsule besides the treatment above .The levels of circulating miR-92 a and left ventricular ejection fraction ( LVEF) before and 4 weeks after treatment were compared between two groups .Results The expression level of circulating miR-92 a after treatment decreased significantly in the therapy group ( P<0 .05 ) , which was lower than that in the control group after treatment (P<0.05).The LVEF levels increased significantly after treatment in both groups in contrast with those before treatment (P<0.05),but there was no significant difference between two groups(P>0.05).The follow-up lasted for 3 months after treatment.The incidence of major adverse cardiac events(MACEs) was 13.0%in the therapy group,and 34.8%in the control group,there was no significant difference in the incidence of MACEs between two groups (P >0.05).Conclusion The treatment with Di′ao Xinxuekang soft capsule following PCI for STEMI patients can make the expression level of circulating miR-92a down-regulation,which does not increase the incidence of MACEs ,no obvious adverse reactions are observed .