CAJ | 학술논문

目的：探讨宫颈鳞癌及宫颈上皮内瘤变（ CIN ）组织中核因子κB （ NF－κB ）的表达及其与宫颈癌临床病理因素的关系。方法采用免疫组化SP法检测正常宫颈20例（对照组），CIN 64例（CINⅠ26例，CINⅡ／Ⅲ38例），宫颈鳞癌45例（宫颈鳞癌组）宫颈组织中NF－κB p65蛋白的表达情况。结果对照组、CINⅠ组、CINⅡ／Ⅲ组、宫颈鳞癌组NF－κB p65蛋白阳性表达率分别为15．00％（3／20）、34．62％（9／26）、47．37％（18／38）、66．67％（30／45）；CINⅡ／Ⅲ组、宫颈鳞癌组NF－κB p65蛋白阳性表达率均明显高于对照组（P＜0．05）；CINⅠ组NF－κBp65蛋白阳性表达率与对照组比较，差异无统计学意义（ P＞0．05）。宫颈鳞癌患者NF－κB p65蛋白阳性表达率与临床分期及淋巴结转移有关（P＜0．05），但与组织学分级、肿瘤直径、年龄等临床病理因素均无明显关系（ P＞0．05）。结论宫颈鳞癌组织中NF－κB p65蛋白异常高表达，其阳性表达率与临床分期及淋巴结转移有关。
목적：탐토궁경린암급궁경상피내류변（ CIN ）조직중핵인자κB （ NF－κB ）적표체급기여궁경암림상병리인소적관계。방법채용면역조화SP법검측정상궁경20례（대조조），CIN 64례（CINⅠ26례，CINⅡ／Ⅲ38례），궁경린암45례（궁경린암조）궁경조직중NF－κB p65단백적표체정황。결과대조조、CINⅠ조、CINⅡ／Ⅲ조、궁경린암조NF－κB p65단백양성표체솔분별위15．00％（3／20）、34．62％（9／26）、47．37％（18／38）、66．67％（30／45）；CINⅡ／Ⅲ조、궁경린암조NF－κB p65단백양성표체솔균명현고우대조조（P＜0．05）；CINⅠ조NF－κBp65단백양성표체솔여대조조비교，차이무통계학의의（ P＞0．05）。궁경린암환자NF－κB p65단백양성표체솔여림상분기급림파결전이유관（P＜0．05），단여조직학분급、종류직경、년령등림상병리인소균무명현관계（ P＞0．05）。결론궁경린암조직중NF－κB p65단백이상고표체，기양성표체솔여림상분기급림파결전이유관。
O bjce tive To explore the relationship between the expression of nuclear factor kappa B ( NF-κB) and the clinicopathological characters in cervical squamous cell carcinoma and cervical intraepithelial neoplasia ( CIN) tissues.Methods Immunohistochemical SP method was used to detect the expression of NF-κBp65 protein in20 cases of normal cervical tissue (control group),64 cases of CIN(26 of CINⅠ,38 of CINⅡ/Ⅲ) and 45 cases of cervical squamous cell carcinoma ( cervical squamous cell carcinoma group ) .Resutl s The positive expression rates of NF-κBp65 protein in the control group ,CINⅠgroup,CINⅡ/Ⅲgroup and cervical squamous cell carcinoma group were 15.00%(3/20), 34.62%(9/26),47.37%(18/38) and 66.67%(30/45),respectively.The positive expression rates of NF-κBp65 protein in CINⅡ/Ⅲand cervical squamous cell carcinoma groups were significantly higher than that in the control group (P<0.05). But there was no significant difference in the positive expression rate of NF-κBp65 protein between CINⅠgroup and control group(P>0.05).The positive expression rate of NF-κBp65 protein correlated with clinical stages and lymph node metastasis ( P<0 .05 ) , but did not significantly correlate with the other clinicopathological characters including histological grade,tumor size and gender (P>0.05).Conclusion The NF-κBp65 protein is overexpressed in cervical squamous cell carcinoma tissues .Its positive expression rate correlates with clinical stages and lymph node metastasis (P>0.05).