中国药师
中國藥師
중국약사
CHINA PHARMACIST
2014年
12期
2100-2101
,共2页
泮托拉唑%奥美拉唑%消化性溃疡出血%疗效
泮託拉唑%奧美拉唑%消化性潰瘍齣血%療效
반탁랍서%오미랍서%소화성궤양출혈%료효
Pantoprazole%Omeprazole%Peptic ulcer bleeding%Clinical curative effect
目的：：比较奥美拉唑与泮托拉唑治疗消化性溃疡出血患者的疗效及不良反应。方法：362例消化性溃疡出血患者随机分为对照组和观察组各181例。对照组予奥美拉唑40 mg+0.9%氯化钠注射液100 ml,ivd,bid；观察组予泮托拉唑80 mg+0.9%氯化钠注射液100 ml,ivd,bid。两组均持续治疗3~6 d。观察记录两组患者呕血、黑便次数、出血情况与出血停止时间；比较两组临床疗效、治疗期间药品不良反应情况和两组药品费用。结果：观察组治疗第1、3 d出血量均明显低于对照组(P <0.05)；观察组平均停止出血时间、平均呕血次数及黑便次数也明显低于对照组(P <0.05)。观察组临床有效率为92.27%,对照组为90.61%,两组比较,差异无统计学意义(P >0.05)。观察组日平均费用明显低于对照组(P <0.05)。两组药品不良反应发生率比较,差异无统计学意义(P >0.05)。结论：消化性溃疡出血患者采用奥美拉唑与泮托拉唑治疗效果相当,均有较高安全性。但泮托拉唑可减少患者呕吐及黑便次数,缩短出血时间,同时治疗费用少。
目的：：比較奧美拉唑與泮託拉唑治療消化性潰瘍齣血患者的療效及不良反應。方法：362例消化性潰瘍齣血患者隨機分為對照組和觀察組各181例。對照組予奧美拉唑40 mg+0.9%氯化鈉註射液100 ml,ivd,bid；觀察組予泮託拉唑80 mg+0.9%氯化鈉註射液100 ml,ivd,bid。兩組均持續治療3~6 d。觀察記錄兩組患者嘔血、黑便次數、齣血情況與齣血停止時間；比較兩組臨床療效、治療期間藥品不良反應情況和兩組藥品費用。結果：觀察組治療第1、3 d齣血量均明顯低于對照組(P <0.05)；觀察組平均停止齣血時間、平均嘔血次數及黑便次數也明顯低于對照組(P <0.05)。觀察組臨床有效率為92.27%,對照組為90.61%,兩組比較,差異無統計學意義(P >0.05)。觀察組日平均費用明顯低于對照組(P <0.05)。兩組藥品不良反應髮生率比較,差異無統計學意義(P >0.05)。結論：消化性潰瘍齣血患者採用奧美拉唑與泮託拉唑治療效果相噹,均有較高安全性。但泮託拉唑可減少患者嘔吐及黑便次數,縮短齣血時間,同時治療費用少。
목적：：비교오미랍서여반탁랍서치료소화성궤양출혈환자적료효급불량반응。방법：362례소화성궤양출혈환자수궤분위대조조화관찰조각181례。대조조여오미랍서40 mg+0.9%록화납주사액100 ml,ivd,bid；관찰조여반탁랍서80 mg+0.9%록화납주사액100 ml,ivd,bid。량조균지속치료3~6 d。관찰기록량조환자구혈、흑편차수、출혈정황여출혈정지시간；비교량조림상료효、치료기간약품불량반응정황화량조약품비용。결과：관찰조치료제1、3 d출혈량균명현저우대조조(P <0.05)；관찰조평균정지출혈시간、평균구혈차수급흑편차수야명현저우대조조(P <0.05)。관찰조림상유효솔위92.27%,대조조위90.61%,량조비교,차이무통계학의의(P >0.05)。관찰조일평균비용명현저우대조조(P <0.05)。량조약품불량반응발생솔비교,차이무통계학의의(P >0.05)。결론：소화성궤양출혈환자채용오미랍서여반탁랍서치료효과상당,균유교고안전성。단반탁랍서가감소환자구토급흑편차수,축단출혈시간,동시치료비용소。
Objective:To compare the efficacy and adverse reactions of omeprazole and pantoprazole in the treatment of patients with peptic ulcer bleeding. Methods: Totally 362 cases of peptic ulcer bleeding were randomly divided into the control group and the observation group with 181 ones in each. The control group was treated by omeprazole 40mg in 0. 9% sodium chloride injection 100ml, ivd, bid, and the observation group was given pantoprazole 80mg in 0. 9% sodium chloride injection 100ml, ivd, bid. The treatment course was 3-6 days. The times of vomiting and melena, bleeding situation and bleeding stopping time in the two groups were observed and recorded, and the clinical efficacy, adverse drug reactions during the treatment and the expense of the two groups were also compared. Results:The bleeding amount on the first and third day in the observation group was significantly lower than that in the control group (P < 0. 05), the average bleeding stopping time and the average times of black stools and vomiting in the observation group were also significantly lower than those in the control group(P < 0. 05). The effective rate of the observation group was 92. 27%, that of the control group was 90. 61%, and the difference was not statistically significant (P >0. 05). The average daily cost of the observation group was significantly lower than that of the control group (P <0. 05). The difference in the incidence of adverse drug reactions of the two groups was not statistically significant (P > 0. 05). Conclusion:The efficacy of omeprazole and pantoprazole in the treatment of peptic ulcer bleeding was similar with high security. However, pantoprazole may reduce the times of vomiting and melena, shorten the bleeding time and decrease the treatment cost.
