CAJ | 학술논문

成盐是改善活性药物分子( API)成药性的一个重要手段，目前活性成分相同而盐基不同的药物不断出现，本文就盐基对药物药动学、药效学及药物不良反应三个方面的影响作简要综述，以对临床遴选治疗药物及新药盐基的选择提供参考。
성염시개선활성약물분자( API)성약성적일개중요수단，목전활성성분상동이염기불동적약물불단출현，본문취염기대약물약동학、약효학급약물불량반응삼개방면적영향작간요종술，이대림상린선치료약물급신약염기적선택제공삼고。
Salt formation is the most important method for increasing druggability of active pharmaceutical ingredients ( API) . Nowadays, API containing different bases are emerging continuously. In this paper, the influence of various bases on the pharmacokinetics, pharmacodynamics and side effects of drugs was reviewed, which can provide reference for the selection of clinical therapeutic drugs and the base choice for new drugs.